CD1B3 Inhibitors
CD1B3 inhibitors pertain to a class of chemical compounds specifically designed to interact with and inhibit the activity of a certain biological target identified by the nomenclature "CD1B3". This target is involved in a complex cascade of biochemical reactions within cellular environments. The inhibitors are characterized by their ability to bind to this target with high specificity, altering its normal function. Through the lens of biochemistry and molecular biology, these inhibitors are fascinating as they represent a fine example of how small molecules can modulate the function of specific proteins. The design of CD1B3 inhibitors often involves a meticulous process of optimization, where the chemical structure of these compounds is fine-tuned to enhance their binding efficiency and specificity to the CD1B3 target.
The development of CD1B3 inhibitors typically involves a rigorous process of chemical synthesis, followed by a series of in vitro assays to determine their efficacy in binding to the CD1B3 protein. These compounds may exhibit a diverse range of structures, with each structure conferring a unique set of properties that affect their interaction with the CD1B3 protein. The molecular architecture of CD1B3 inhibitors is crucial, as it determines the nature of the interaction with the target protein, including the strength and duration of inhibition. Researchers in the field of chemical biology and medicinal chemistry invest significant effort into elucidating the mechanisms by which these inhibitors exert their action at the molecular level. Such studies usually involve a detailed analysis of the interaction between the inhibitor and the target, which can include binding affinity studies, structural biology techniques such as X-ray crystallography or NMR spectroscopy, and computational modeling to predict and visualize how these inhibitors fit into the active site of the CD1B3 protein.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). CD1B3 is involved in antigen presentation and its activity can be influenced by the PI3K signaling pathway. Inhibition of PI3K by Wortmannin could lead to reduced activation of downstream pathways, thereby affecting the functional activity of CD1B3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another specific inhibitor of PI3K, which plays a role in immune cell signaling. By inhibiting PI3K, LY294002 may alter the cellular processes that affect the presentation of lipid antigens by CD1B3, leading to decreased functional activity of CD1B3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a key downstream effector of PI3K. Since mTOR signaling can affect the presentation of antigens by influencing cellular processes, blocking this pathway with Rapamycin could indirectly inhibit the activity of CD1B3. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive agent that inhibits calcineurin, ultimately leading to the inhibition of the transcription factor NFAT. NFAT is involved in the regulation of immune responses, which could affect the expression and function of CD1B3 in antigen-presenting cells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 could interfere with signaling events that regulate the expression or activity of CD1B3 in immune cells. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which is involved in the response to stress and inflammatory cytokines. Inhibition of p38 MAPK could affect the functional activity of CD1B3 by altering the intracellular signaling involved in its regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, preventing the activation of the ERK pathway. ERK pathway signaling influences various immune cell functions, which may indirectly decrease the functional activity of CD1B3 in antigen presentation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in the immune response. By inhibiting JNK, SP600125 could indirectly affect the pathways that influence CD1B3 function within immune cells. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, which is crucial for the proper processing and presentation of antigens by CD1B3. This disruption can lead to a decrease in the functional activity of CD1B3. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, which is involved in the regulation of immune responses. By preventing NF-κB activation, BAY 11-7082 could lead to reduced expression or activity of CD1B3 in antigen-presenting cells. | ||||||