CD161 Activators

CD161 activators encompass a range of chemical compounds that can enhance the functional activity of the CD161 protein either directly or indirectly. Some activators function by influencing key upstream regulators of multiple signaling pathways, such as PKC and PI3K, or by manipulating cAMP levels, which can lead to the activation of PKA. The activation of these kinases and the subsequent phosphorylation of various downstream proteins can lead to the activation of CD161. For instance, Phorbol Myristate Acetate (PMA) is a potent activator of PKC, thereby indirectly influencing CD161. Similarly, Forskolin and IBMX elevate cAMP levels, indirectly activating CD161 through PKA.

Other compounds function by inhibiting specific proteins or enzymes, thereby shifting the balance of signaling towards other pathways that can lead to the activation of CD161. Bisindolylmaleimide I, Calphostin C, LY294002, Wortmannin, U73122, H89, Staurosporine, and Okadaic Acid are examples of such inhibitors. By inhibiting PKC, PI3K, PLC, PKA, various protein kinases, and PP2A respectively, these compounds can trigger signaling events that lead to the increased functional activity of CD161. For instance, LY294002 and Wortmannin, by inhibiting PI3K, can shift the balance of signaling towards pathways that lead to the activation of CD161.