CD161 Activators
CD161 activators encompass a range of chemical compounds that can enhance the functional activity of the CD161 protein either directly or indirectly. Some activators function by influencing key upstream regulators of multiple signaling pathways, such as PKC and PI3K, or by manipulating cAMP levels, which can lead to the activation of PKA. The activation of these kinases and the subsequent phosphorylation of various downstream proteins can lead to the activation of CD161. For instance, Phorbol Myristate Acetate (PMA) is a potent activator of PKC, thereby indirectly influencing CD161. Similarly, Forskolin and IBMX elevate cAMP levels, indirectly activating CD161 through PKA.
Other compounds function by inhibiting specific proteins or enzymes, thereby shifting the balance of signaling towards other pathways that can lead to the activation of CD161. Bisindolylmaleimide I, Calphostin C, LY294002, Wortmannin, U73122, H89, Staurosporine, and Okadaic Acid are examples of such inhibitors. By inhibiting PKC, PI3K, PLC, PKA, various protein kinases, and PP2A respectively, these compounds can trigger signaling events that lead to the increased functional activity of CD161. For instance, LY294002 and Wortmannin, by inhibiting PI3K, can shift the balance of signaling towards pathways that lead to the activation of CD161.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), a key upstream regulator of many signaling pathways. CD161, being a C-type lectin receptor, can be indirectly influenced by PKC activation. PKC activation may lead to the phosphorylation of different downstream proteins, thereby leading to the potential activation of CD161. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. By inhibiting PKC, it can shift the balance of signaling towards other pathways that might lead to the activation of CD161. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in many signaling pathways and by inhibiting PI3K, it can potentially shift the balance towards pathways that can lead to activation of CD161. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, Wortmannin can potentially shift the balance of signaling towards other pathways that might lead to the activation of CD161. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which lead to an increase in cAMP levels. Increased cAMP levels can activate protein kinase A (PKA), which might lead to the activation of CD161. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific PDE inhibitor that leads to increased cAMP levels, which can activate PKA. PKA might subsequently lead to the activation of CD161. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a PDE4 inhibitor. By inhibiting PDE4, it can lead to increased cAMP levels, potentially leading to the activation of CD161 through PKA. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a PKA inhibitor. By inhibiting PKA, it can potentially shift the balance of signaling towards other pathways that might lead to the activation of CD161. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a PP2A inhibitor. PP2A is a key regulator of many signaling pathways, and by inhibiting it, the balance of signaling might be shifted towards pathways that activate CD161. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a non-specific protein kinase inhibitor. By inhibiting multiple kinases, it may shift the balance of signaling towards pathways that lead to the activation of CD161. | ||||||