CD160 Inhibitors
CD160 inhibitors are a class of chemical compounds that primarily target and modulate the CD160 protein, a cell surface glycoprotein belonging to the immunoglobulin superfamily. CD160, also known as Natural Killer Cell Receptor BY55 (NKp46), is expressed on various immune cells, including natural killer (NK) cells, T cells, and some subsets of B cells. Its role in the immune system revolves around regulating immune responses, particularly in the context of cytotoxicity and cytokine production. CD160 inhibitors are designed to interact with CD160, altering its activity or signaling pathways to influence immune cell function.
These inhibitors work through different mechanisms, such as blocking CD160's binding to its ligand HVEM (Herpesvirus Entry Mediator) or inhibiting downstream signaling pathways activated upon CD160 engagement. By modulating CD160, these compounds can potentially impact immune responses in various ways, including regulating the cytotoxicity of NK cells and the production of pro-inflammatory cytokines by T cells. The development and study of CD160 inhibitors are particularly relevant in the field of immunology, where a deeper understanding of immune cell regulation can contribute to insights into immune-related diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $156.00 $339.00 | 59 | |
This compound can inhibit Janus kinases which are upstream of many signaling pathways, potentially altering CD160 expression or function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can affect CD160 downstream signaling by altering T cell activation and co-stimulation signals. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src family kinase inhibitor that can modulate T cell receptor pathways, possibly affecting CD160 signaling. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
A selective JAK1/2 inhibitor that can influence cytokine signaling, possibly impacting CD160 levels or function in T cells. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Inhibits STAT3 activation and dimerization, potentially altering CD160 expression in immune cells. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can affect T cell differentiation and function, potentially impacting CD160 expression. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
A tyrosine kinase inhibitor that can suppress T cell activation, potentially modulating CD160 signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can affect inflammatory responses, possibly influencing CD160 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor like LY294002, can affect T cell activation and potentially influence CD160 expression or function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which works upstream of ERK, could influence signaling pathways associated with CD160. | ||||||