CCDC77 Inhibitors
Chemical inhibitors of CCDC77 act primarily by disrupting the function of cyclin-dependent kinases (CDKs), which are essential for the regulation of the cell cycle. Alsterpaullone, for instance, is a potent inhibitor targeting these kinases, thereby interrupting the cell cycle machinery that CCDC77 is part of. Similarly, Roscovitine and Olomoucine are selective CDK inhibitors which interfere with the progression of the cell cycle. The disruption caused by these chemicals leads to an inhibition of CCDC77 function, as it is unable to participate in cell cycle events without proper CDK activity. Indirubin-3'-monoxime, while also inhibiting CDKs, targets GSK-3β as well, affecting the phosphorylation state of proteins involved in cell cycle regulation, which in turn inhibits the functionality of CCDC77. Isoxazole 9 is another CDK inhibitor, noted for its specificity towards CDK2, and hence, it can inhibit CCDC77 by interfering with cell cycle regulation.
Continuing with this theme, Purvalanol A, CR8 (a derivative of Roscovitine), and SNS-032 are all potent CDK inhibitors. Their ability to cause cell cycle arrest translates into an indirect inhibition of CCDC77 by stopping the cell cycle processes that the protein supports. AT7519's broad-spectrum inhibition of CDKs further reinforces this method of inhibition by preventing CCDC77 from aiding in cell cycle progression. Dinaciclib, with its robust inhibition of multiple CDKs, similarly prevents the normal progression of the cell cycle, which is crucial for CCDC77's function. AZD5438, which inhibits CDK1, 2, and 9, disrupts both the cell cycle and transcription regulation, leading to an effective inhibition of CCDC77. Lastly, Flavopiridol, known for its ability to induce cell cycle arrest by inhibiting several CDKs, also contributes to the inhibition of CCDC77 by halting the processes it is involved in.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a potent inhibitor of cyclin-dependent kinases (CDKs), and since CCDC77 is involved in cell cycle progression, inhibiting CDKs can disrupt the processes that CCDC77 supports, leading to its functional inhibition due to disruption of the cell cycle machinery. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine selectively inhibits CDKs which are integral to the cell cycle and transcriptional regulation. CCDC77, playing a role in these processes, would be functionally inhibited as the downstream effects of CDK inhibition would impair the cell cycle and transcription events that require CCDC77 function. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is another CDK inhibitor that can halt cell cycle progression. By blocking CDKs, the activity of CCDC77 is indirectly inhibited as it cannot perform its role in the cell cycle without proper CDK function. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
This chemical is a known inhibitor of CDKs and glycogen synthase kinase 3β (GSK-3β). By inhibiting these kinases, it affects the phosphorylation state of proteins involved in cell cycle regulation, potentially leading to a functional inhibition of CCDC77 through disrupted cell cycle progression. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a potent inhibitor of CDKs. Since CCDC77 is implicated in cell cycle related functions, the inhibition of CDKs would lead to a functional inhibition of CCDC77 by preventing the cell cycle events that CCDC77 would typically support or engage with. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is known to inhibit multiple CDKs. Given the role of CCDC77 in cell cycle and possibly transcriptional regulation, inhibition of these CDKs would disrupt the pathways and processes CCDC77 is involved in, leading to its functional inhibition. | ||||||
AT7519 | 844442-38-2 | sc-364416 sc-364416A sc-364416B sc-364416C | 5 mg 10 mg 100 mg 1 g | $291.00 $341.00 $1046.00 $3126.00 | 1 | |
AT7519 is a multi-CDK inhibitor that can interfere with several phases of the cell cycle. Since CCDC77 is associated with cell cycle regulation, the inhibition of CDKs by AT7519 would functionally inhibit CCDC77 by preventing the proper progression of the cell cycle. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Dinaciclib robustly inhibits several CDKs. By disrupting the activity of these kinases, the cell cycle cannot proceed normally, which would functionally inhibit CCDC77 by not allowing it to carry out its associated activities within the cell cycle, leading to a functional inhibition of CCDC77's role. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 is an inhibitor of CDK1, 2, and 9. The inhibition of these kinases would disrupt the cell cycle and transcription regulation, processes in which CCDC77 is implicated. This disruption would lead to the functional inhibition of CCDC77 as it cannot participate in its normal cellular functions without the action of these kinases. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits several CDKs and can induce cell cycle arrest. The functional inhibition of CCDC77 would occur as a result of the disruption of normal cell cycle progression, which is critical for CCDC77's activity, leading to a functional inhibition of the processes CCDC77 is known to be involved in. | ||||||