CCDC74A Activators
CCDC74A activators, in this context, are chemicals that influence cellular pathways, particularly cell cycle regulation, to indirectly bring about the stabilization and activation of CCDC74A. Agents like Roscovitine and Purvalanol A inhibit CDKs at different cell cycle transitions, namely the G1/S and G2/M transition respectively, and thus stabilize CCDC74A, facilitating its activation. Likewise, compounds such as MG132 and Etoposide act as proteasome and topoisomerase II inhibitors, respectively, leading to an arrest in the cell cycle and the subsequent stabilization of CCDC74A.
Similarly, SB-218078 and Zeocin influence cell cycle checkpoints and DNA integrity. SB-218078 inhibits Chk1, disrupting cell cycle checkpoints and thereby facilitating CCDC74A activation. Zeocin is a DNA-damaging agent that causes cell cycle arrest, which also leads to the activation of CCDC74A by stabilization. In summary, the chemicals listed here work by affecting cellular pathways that ultimately lead to the stabilization and activation of CCDC74A.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Inhibits CDKs, leading to cell cycle arrest at the G1/S transition, promoting CCDC74A stabilization and activation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that stabilizes CCDC74A by preventing its degradation, thereby indirectly activating it. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Inhibits CDKs and disrupts the cell cycle at the G2/M transition, facilitating CCDC74A stabilization and activation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Demethylating agent that can increase the expression of CCDC74A by affecting DNA methylation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, leading to cell cycle arrest and stabilization of CCDC74A, indirectly activating it. | ||||||
N-6-(Δ2-Isopentenyl)-adenine | 2365-40-4 | sc-279669 sc-279669A sc-279669B sc-279669C sc-279669D | 1 g 5 g 10 g 50 g 100 g | $133.00 $467.00 $923.00 $4595.00 $8165.00 | 1 | |
Cytokinin that activates cyclin-dependent kinases (CDKs), facilitating CCDC74A's role in cell cycle regulation. | ||||||
SB 218078 | 135897-06-2 | sc-203692 | 1 mg | $133.00 | 1 | |
Inhibits Chk1, disrupting cell cycle checkpoints and leading to CCDC74A stabilization and activation. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Myosin II inhibitor that alters cytoskeleton dynamics, leading to stabilization and activation of CCDC74A. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
CDK4/6 inhibitor causing cell cycle arrest, leading to stabilization and activation of CCDC74A. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, causing cell cycle arrest and leading to CCDC74A stabilization and activation. | ||||||