CCDC60_Ccdc60 Inhibitors
CCDC60 inhibitors encompass a diverse group of chemical compounds that affect various signaling pathways and cellular processes, which in turn can indirectly inhibit the functional activity of CCDC60. These inhibitors do not directly target CCDC60 but interfere with the pathways and processes that CCDC60 is involved in, particularly those related to ciliogenesis and ciliary function. For instance, protein kinase inhibitors like Staurosporine inhibit kinases that regulate ciliary beat frequency, thus affecting CCDC60's role in ciliary function. Cyclin-dependent kinase inhibitors such as Roscovitine can prevent the assembly or function of cilia, where CCDC60 is implicated, by halting the cell cycle. Similarly, the Raf kinase inhibitor GW5074 and the MEK inhibitor PD98059 disrupt the MAPK/ERK pathway, thereby potentially altering CCDC60's ciliary-related activities.
Compounds like LY294002 and Rapamycin target the PI3K/Akt and mTOR pathways, respectively, both of which are critical for ciliogenesis and ciliary function, processes where CCDC60 is functionally relevant. Inhibitors of cytoskeletal dynamics, such as Blebbistatin and Y-27632, interfere with the organization of actin and myosin II, which is essential for proper ciliary assembly and function, thereby affecting CCDC60's associated activities.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Protein kinase inhibitor that targets a wide range of kinases including PKA, PKC, and PKG. CCDC60, associated with ciliary function, can be indirectly inhibited as these kinases are involved in ciliogenesis and ciliary beat frequency regulation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Cyclin-dependent kinase inhibitor that affects CDK1, CDK2, CDK5, and CDK7. Since CCDC60 is implicated in cell-cycle progression through its involvement in cilia, inhibiting CDKs would prevent cilia assembly or function, indirectly inhibiting CCDC60 activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Raf kinase inhibitor which interrupts the MAPK/ERK pathway. CCDC60, linked with cellular signaling pathways, would have reduced functionality due to the disruption of downstream effects on ciliary processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that impedes the PI3K/Akt signaling pathway. As ciliogenesis and ciliary function are influenced by this pathway, CCDC60's role in cilia could be indirectly inhibited by altering signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that can regulate autophagy and ciliogenesis. Since CCDC60 is associated with ciliary structure and function, its activity would be indirectly inhibited through mTOR pathway modulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that affects the JNK signaling pathway. JNK pathway influences ciliary dynamics; thus, CCDC60's function related to cilia would be indirectly inhibited by disrupting this signaling. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Myosin II inhibitor that prevents myosin II from binding to actin, disrupting cytoskeletal dynamics. Since ciliogenesis and ciliary function require proper cytoskeletal organization, CCDC60's associated activities are indirectly affected. | ||||||
Vandetanib | 443913-73-3 | sc-220364 sc-220364A | 5 mg 50 mg | $167.00 $1353.00 | ||
VEGFR inhibitor that also affects RET kinase. By inhibiting RET kinase, which has roles in ciliogenesis, CCDC60's function in ciliary processes would be indirectly influenced. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor that interferes with the p38 MAPK signaling pathway. Given the role of p38 MAPK in ciliary length and function, CCDC60's activity related to ciliary processes would be indirectly inhibited. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that affects the MAPK/ERK pathway. Ciliogenesis and ciliary function are regulated by this pathway, and thus, CCDC60's activity would be indirectly inhibited. | ||||||