CCDC22 Activators
CCDC22 Activators are a suite of chemical compounds that boost the functional activity of CCDC22 by modulating various cell-signaling pathways. Forskolin, 8-Bromo-cAMP, and Dibutyryl cAMP upregulate cAMP levels, which in turn activate PKA. The subsequent phosphorylation cascade may enhance CCDC22 activity by affecting the signaling complexes it is associated with. Similarly, Ionomycin's calcium ionophore activity and Calyculin A's inhibition of protein phosphatases promote a cellular state where calcium-dependent proteins and phosphorylation events can potentiate CCDC22's role in signal transduction. PMA's activation of PKC adds another layer of modulation, wherein PKC-mediated phosphorylation of proteins could also bolster CCDC22 function.
On the other hand, compounds like SF1670, by inhibiting PTEN, lead to amplified PI3K signaling, inadvertently enhancing CCDC22 activity through downstream signaling events. LY294002, albeit a PI3K inhibitor, may invoke alternative pathways that compensate by activating CCDC22. Epigallocatechin Gallate (EGCG) and Olaparib, by targeting protein kinases and PARP respectively, could alter the cellular signaling landscape, potentially upregulating CCDC22's activity in those modified contexts. Anisomycin's induction of stress pathways and Zaprinast's elevation of cyclic nucleotides further exemplify how diverse mechanisms, from stress response to cAMP/PKG signaling, can be exploited to enhance CCDC22's activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels within cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins, including those that may be in complex with CCDC22, thus enhancing CCDC22's functional activity in cellular processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin functions as a calcium ionophore, increasing intracellular calcium concentration. This rise in calcium can activate calcium-dependent signaling pathways, which may indirectly enhance the functional activity of CCDC22 by promoting its involvement in cellular signaling networks. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which modulates numerous signaling pathways. PKC activation can result in the phosphorylation of proteins that interact with CCDC22 or are part of its signaling complex, enhancing CCDC22's role in these pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog is resistant to degradation by phosphodiesterases and thus effectively raises intracellular cAMP levels. The result is sustained PKA activation which could enhance CCDC22-associated signaling pathways through phosphorylation events. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
SF1670 is a potent inhibitor of PTEN, a phosphatase that opposes PI3K/Akt signaling. Inhibition of PTEN leads to enhanced PI3K/Akt pathway activity, which could indirectly enhance the functional activity of CCDC22 in related signaling cascades. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
As an inhibitor of certain protein phosphatases, Calyculin A can prevent dephosphorylation of proteins within CCDC22's signaling network. This sustained phosphorylation state could enhance the activity of pathways involving CCDC22. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit several protein kinases and has been shown to alter signaling pathways. By affecting these kinases, EGCG may shift the balance of cellular signaling to enhance pathways in which CCDC22 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which paradoxically can lead to the activation of compensatory signaling pathways that could enhance the function of CCDC22 in cellular signaling. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
As a PARP inhibitor, Olaparib may influence DNA repair pathways. The alteration in DNA repair mechanisms could indirectly enhance CCDC22 activity if it is part of the cellular response to DNA damage. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin interferes with protein synthesis by inhibiting peptidyl transferase. This stress can activate stress-activated protein kinase (SAPK) pathways, which may enhance the signaling roles of CCDC22 in stress responses. | ||||||