Date published: 2025-9-5

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CB1 Activators

CB1 activators constitute a unique class of compounds designed to interact with the cannabinoid receptor type 1 (CB1), a crucial player in the central nervous system. These molecules, with diverse structures, modulate the endocannabinoid system, a pivotal regulator of various physiological processes. CB1 activators influence intricate signaling pathways, showcasing their impact on cellular responses. This class exhibits structural diversity, ranging from endogenous cannabinoids to synthetic derivatives. Notably, some members mimic endogenous cannabinoids, while others showcase distinct chemical backbones. This structural variability underscores the adaptability of CB1 activators, allowing them to interact with CB1 receptors in unique ways. CB1 activators exert their effects by binding to CB1 receptors, initiating complex intracellular signaling events. The class encompasses compounds with diverse pharmacological implications, influencing processes such as pain modulation and synaptic plasticity. Their ability to modulate neurotransmitter release highlights the functional significance of CB1 activators in cellular communication. Some CB1 activators demonstrate neuroprotective properties, hinting at their potential in mitigating excitotoxicity. Others exhibit vasorelaxant effects, showcasing the class's impact on peripheral systems. The functional significance of CB1 activators lies in their ability to influence various physiological responses, providing a broad spectrum of applications. Understanding the molecular dynamics of CB1 activators is crucial for unraveling their biological effects. These compounds interact with CB1 receptors, influencing downstream cellular responses. The intricate balance between structural features and receptor binding dynamics within the CB1 activator class contributes to their potency and prolonged effects. In summary, CB1 activators represent a versatile class of compounds that impact diverse physiological processes through their interaction with CB1 receptors. The structural variability and pharmacological implications of this class make it a fascinating area of research, offering insights into novel pathways in neuroscience and cellular signaling. As researchers delve deeper, the promise of uncovering new pharmacological targets and mechanisms within the CB1 activator class continues to drive scientific exploration.

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Items 21 to 25 of 25 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dihomo-γ-linolenylethanolamide

150314-34-4sc-202137
5 mg
$55.00
(0)

Dihomo-γ-linolenylethanolamide acts as a selective CB1 receptor modulator, distinguished by its unique polyunsaturated fatty acid backbone. This compound engages in specific hydrophobic interactions and forms critical van der Waals contacts with receptor sites, enhancing its binding efficacy. Its structural flexibility allows for dynamic conformational changes, influencing receptor activation pathways. Additionally, its unique lipid solubility may affect membrane permeability and distribution, providing insights into its role in cellular signaling mechanisms.

Yangonin

500-62-9sc-205889
sc-205889A
5 mg
10 mg
$268.00
$510.00
1
(0)

Yangonin is a notable compound that selectively interacts with the CB1 receptor, characterized by its unique structural features that facilitate specific hydrogen bonding and hydrophobic interactions. Its distinct molecular conformation allows for effective receptor engagement, influencing downstream signaling pathways. The compound's lipophilicity enhances its affinity for lipid membranes, potentially impacting its distribution and interaction dynamics within cellular environments, thereby modulating various physiological responses.

MDA 19

1048973-47-2sc-358804
sc-358804A
1 mg
5 mg
$28.00
$122.00
(0)

MDA 19 exhibits a remarkable affinity for the CB1 receptor, driven by its unique steric configuration that promotes specific van der Waals interactions. This compound's ability to stabilize receptor conformations enhances its binding efficacy, leading to distinct allosteric modulation of signaling pathways. Additionally, MDA 19's high lipophilicity contributes to its rapid membrane permeability, influencing its kinetic profile and interaction with lipid bilayers, which may alter cellular signaling cascades.

CB-52

sc-221404
sc-221404A
1 mg
5 mg
$39.00
$173.00
(0)

CB-52 demonstrates a distinctive interaction with the CB1 receptor, characterized by its unique electronic distribution that facilitates strong hydrogen bonding and dipole-dipole interactions. This compound's structural flexibility allows it to adopt multiple conformations, enhancing its ability to engage with the receptor's active site. Furthermore, CB-52's moderate hydrophobicity influences its solubility in various environments, potentially affecting its diffusion rates and overall bioavailability in cellular systems.

Arachidonoyl-1-thio-Glycerol

1309664-54-7sc-221265
sc-221265A
1 mg
5 mg
$45.00
$202.00
(0)

Arachidonoyl-1-thio-Glycerol exhibits a remarkable affinity for the CB1 receptor, driven by its unique thiol group that enhances its reactivity and interaction dynamics. This compound's stereochemistry allows for specific spatial arrangements that optimize binding efficiency. Additionally, its lipid-like characteristics contribute to membrane permeability, influencing its kinetic behavior in cellular environments. The compound's ability to form transient complexes may also modulate receptor signaling pathways effectively.