CaT1 Inhibitors
Chemical inhibitors of CaT1 include a variety of compounds that target calcium channels, particularly those classified as T-type. Mibefradil directly blocks these channels, and since CaT1 is part of this family, it prevents calcium entry, effectively inhibiting CaT1's function. Similarly, the dihydropyridine calcium channel blocker Nifedipine, while preferentially targeting L-type channels, also shares an inhibitory effect on CaT1 by diminishing the calcium influx where CaT1 is active. Non-selective inhibitors such as Nickel Chloride act by binding to the channel pore or associated sites of T-type channels including CaT1, which impedes the channel's ability to conduct calcium.
Additionally, Ethosuximide serves as a direct blocker of T-type calcium channels, reducing CaT1 activity by preventing ion entry through these pathways. Zinc and Cadmium Chloride are non-specific in their action but nonetheless inhibit CaT1 through binding at the extracellular side of the channel or directly to the channel, obstructing the ion conduction pathway. Flunarizine and Verapamil inhibit T-type channels by stabilizing their inactivated state and by blocking calcium influx, respectively, which includes channels containing CaT1. Furthermore, Benzothiazepine derivatives like diltiazem bind to the channels to hinder calcium entry, thus inhibiting CaT1. Finally, Pentamidine alters the electrochemical gradient necessary for calcium entry through T-type channels, which can inhibit CaT1, while Magnesium competes with calcium ions at high concentrations, reducing the entry through the channel and inhibiting CaT1's activity. These chemical interactions with T-type calcium channels and the consequent inhibition of calcium entry are critical to the functional inhibition of CaT1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $213.00 $865.00 | 4 | |
Mibefradil blocks T-type calcium channels, which can inhibit CaT1 as this protein is a member of the T-type calcium channel family. Blocking these channels prevents Ca2+ entry into cells, directly inhibiting CaT1-mediated currents. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a dihydropyridine calcium channel blocker that preferentially inhibits L-type calcium channels but can also inhibit CaT1 by reducing the overall calcium influx through voltage-gated calcium channels where CaT1 is present. | ||||||
Nickel(II) chloride | 7718-54-9 | sc-236169 sc-236169A | 100 g 500 g | $68.00 $188.00 | ||
Nickel Chloride is known to non-selectively inhibit multiple calcium channels, including T-type calcium channels where CaT1 is a component, by binding to the channel pore or associated sites, impeding calcium entry through these channels. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride indirectly inhibits CaT1 by blocking epithelial sodium channels (ENaC), leading to altered membrane potential which can affect the driving force for calcium entry through T-type calcium channels. | ||||||
Ethosuximide | 77-67-8 | sc-211431 | 1 g | $306.00 | ||
Ethosuximide is a known T-type calcium channel blocker, which by inhibiting these channels, directly reduces CaT1 activity by preventing calcium ions from entering through these specific channels. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can non-specifically inhibit calcium channels, including T-type channels where CaT1 is present, by binding to the extracellular side and obstructing the ion conduction pathway. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium Chloride is another non-specific blocker of calcium channels, which can inhibit CaT1 by binding to the channel and preventing calcium ion conduction. | ||||||
Flunarizine | 52468-60-7 | sc-337841 | 5 g | $560.00 | ||
Flunarizine has been shown to inhibit T-type calcium channels, and thus it can inhibit CaT1 by stabilizing the inactivated state of the channel, reducing calcium entry. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a phenylalkylamine calcium channel blocker that, while mainly targeting L-type channels, can also inhibit CaT1-containing T-type channels, blocking calcium influx. | ||||||
Pentamidine | 100-33-4 | sc-208158 sc-208158A | 25 mg 50 mg | $380.00 $568.00 | ||
Pentamidine is known to block several types of ion channels and could inhibit CaT1 by altering the electrochemical gradient necessary for calcium entry through T-type channels. | ||||||