Date published: 2026-6-6

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CASK Inhibitors

CASK inhibitors represent a diverse class of compounds that exert their influence on CASK activity through intricate modulation of specific signaling pathways. These compounds act indirectly, either by disrupting pathways directly interacting with CASK or by altering cellular processes linked to CASK function. One such group includes MEK inhibitors like U0126 and PD98059, which attenuate the MAPK pathway, impacting CASK's interaction with components of this cascade. Additionally, PI3K inhibitors like Wortmannin and LY294002 interfere with the PI3K/Akt pathway, disrupting the intricate interplay between Akt and CASK. These disruptions lead to downstream effects that modulate CASK activity. Furthermore, compounds such as H89, a PKA inhibitor, and H1152, a ROCK inhibitor, indirectly influence CASK by affecting cAMP-dependent pathways and the Rho/ROCK pathway, respectively. These inhibitors create a molecular environment that alters CASK function through intricate signaling cascades. The intricacies of CASK regulation are further explored by compounds like A769662, an AMPK activator, and SB216763, a GSK-3 inhibitor. A769662 modulates AMPK-dependent pathways connected to CASK, while SB216763 influences the Wnt/β-catenin pathway, impacting CASK through this intricate network. In summary, CASK inhibitors encompass a nuanced array of chemicals that intricately modulate cellular signaling pathways, indirectly impacting CASK activity.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

KN-93

139298-40-1sc-202199
1 mg
$182.00
25
(1)

KN-93, a CaMKII inhibitor, indirectly influences CASK by modulating calcium signaling. CaMKII regulates CASK expression, and KN-93 inhibits this regulation, resulting in altered CASK activity through the modulation of calcium-dependent signaling pathways.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126, a MEK inhibitor, indirectly affects CASK by suppressing the MAPK pathway. CASK interacts with components of the MAPK cascade, and U0126 disrupts this pathway, leading to downstream effects that influence CASK function.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin, a PI3K inhibitor, indirectly modulates CASK by interfering with the PI3K/Akt pathway. CASK interacts with Akt, and Wortmannin disrupts this pathway, resulting in altered CASK activity through the modulation of PI3K-dependent signaling pathways.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580, a p38 MAPK inhibitor, indirectly affects CASK by suppressing the p38 MAPK pathway. CASK interacts with components of this pathway, and SB203580 disrupts it, resulting in altered CASK activity through the modulation of p38 MAPK-dependent signaling pathways.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125, a JNK inhibitor, indirectly modulates CASK by suppressing the JNK signaling pathway. CASK interacts with JNK, and SP600125 disrupts this pathway, leading to downstream effects that influence CASK function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002, a PI3K inhibitor, indirectly influences CASK by interfering with the PI3K/Akt pathway. CASK interacts with Akt, and LY294002 disrupts this pathway, resulting in altered CASK activity through the modulation of PI3K-dependent signaling pathways.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059, a MEK inhibitor, indirectly affects CASK by suppressing the MAPK pathway. CASK interacts with components of the MAPK cascade, and PD98059 disrupts this pathway, leading to downstream effects that influence CASK function.

H-1152 dihydrochloride

451462-58-1sc-203592
sc-203592A
1 mg
5 mg
$104.00
$364.00
7
(1)

H1152, a ROCK inhibitor, indirectly modulates CASK by suppressing the Rho/ROCK pathway. CASK interacts with ROCK, and H1152 disrupts this pathway, resulting in altered CASK activity through the modulation of Rho/ROCK-dependent signaling pathways.

A-769662

844499-71-4sc-203790
sc-203790A
sc-203790B
sc-203790C
sc-203790D
10 mg
50 mg
100 mg
500 mg
1 g
$184.00
$741.00
$1076.00
$3417.00
$5304.00
23
(2)

A769662, an AMPK activator, indirectly influences CASK by modulating AMPK-dependent pathways. CASK is connected to AMPK signaling, and A769662 activates AMPK, leading to downstream effects that influence CASK function.

SB-216763

280744-09-4sc-200646
sc-200646A
1 mg
5 mg
$71.00
$202.00
18
(1)

SB216763, a GSK-3 inhibitor, indirectly affects CASK by modulating the Wnt/β-catenin pathway. CASK interacts with GSK-3, and SB216763 disrupts this pathway, resulting in altered CASK activity through the modulation of Wnt/β-catenin-dependent signaling pathways.