CASC1 Activators
The class of compounds known as CASC1 Activators encompasses a range of molecules that indirectly enhance the functional activity of the CASC1 protein through manipulation of intracellular cAMP levels. Such chemicals include Forskolin, which directly stimulates adenylyl cyclase, thereby leading to elevated cAMP concentrations that facilitate CASC1 activity within cAMP-dependent signaling networks. Similarly, Histamine and Epinephrine, through their specific receptors, activate adenylyl cyclase, resulting in the amplification of cAMP-mediated signaling conducive to CASC1 function. The role of cAMP in cellular signaling is crucial for the activation of CASC1, as it serves as a secondary messenger that triggers various downstream effects. The inhibition of phosphodiesterases by compounds like IBMX, Rolipram, Anagrelide, Cilostamide, Luteolin, and Zardaverine contributes to this process by preventing cAMP breakdown, thereby sustaining a state that promotes CASC1 activity. Anagrelide and Cilostamide, withspecific actions on phosphodiesterase 3, and Rolipram and Zardaverine, with their selectivity towards phosphodiesterase 4, lead to prolonged cAMP signals that indirectly support CASC1 activity.
In addition to these pharmacological agents, endogenous hormones like Epinephrine and Glucagon also play a role in the indirect activation of CASC1. By binding to their respective receptors, they trigger adenylyl cyclase activity, which in turn enhances cAMP levels. Elevated cAMP acts as a pivotal messenger in the cAMP-dependent pathways, which are intimately linked to the functional enhancement of CASC1. Prostaglandin E1 (PGE1) and Dopamine further add to this group, exerting their effects through receptor-mediated adenylyl cyclase activation, underscoring the diverse yet specific mechanisms through which cAMP levels can be modulated. Collectively, these CASC1 Activators demonstrate a concerted action on cAMP signaling, ensuring that CASC1 function is potentiated through a sustained and amplified second messenger response. This highlights the intricate network of intracellular signals that converge on the modulation of CASC1, a protein that is evidently regulated by the nuanced equilibrium of cAMP concentrations within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. CASC1, being a part of cAMP-dependent pathways, is functionally enhanced as cAMP acts as a second messenger in various signal transduction processes, thus indirectly increasing CASC1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases. By preventing cAMP breakdown, IBMX indirectly sustains the cAMP signaling that promotes CASC1 activation through prolonged cAMP-dependent signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
As a hormone and a neurotransmitter, epinephrine binds to adrenergic receptors, which can stimulate adenylyl cyclase activity, thus elevating cAMP levels. Elevated cAMP indirectly enhances CASC1 activity through the activation of cAMP-dependent pathways. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Prostaglandin E1 binds to its E-prostanoid receptors, which are coupled with G-proteins that activate adenylyl cyclase. The subsequent rise in cAMP levels indirectly supports CASC1 functional activity through cAMP-mediated signaling pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its H2 receptor subtype, activates adenylyl cyclase, which increases intracellular cAMP levels, thus indirectly enhancing CASC1 function by engaging cAMP-dependent signaling pathways. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, via its D1-like receptors, activates adenylyl cyclase, increasing cAMP levels. Increased cAMP indirectly augments CASC1 functionality within the associated cAMP signal transduction cascades. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which hydrolyzes cAMP. Inhibition of PDE4 leads to increased cAMP levels, indirectly promoting CASC1 activation through sustained cAMP signaling. | ||||||
Anagrelide hydrochloride | 58579-51-4 | sc-203513 sc-203513A | 10 mg 50 mg | $103.00 $587.00 | 1 | |
Anagrelide is a phosphodiesterase 3 inhibitor. By inhibiting PDE3, it increases cAMP levels, which indirectly enhances CASC1 activity by amplifying the cAMP-dependent signaling pathways. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide specifically inhibits phosphodiesterase 3, resulting in increased cAMP levels, which can indirectly lead to enhanced CASC1 activity through cAMP-mediated signaling pathways. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is known to inhibit phosphodiesterase activities, thereby increasing cAMP levels and indirectly supporting the functional activity of CASC1 through extended cAMP signaling. | ||||||