CAMTA1 Activators
The chemical class of CAMTA1 Activators is diverse because it includes compounds that function by modulating different cellular processes which could indirectly result in the activation of CAMTA1. These chemicals often target primary messengers or signaling pathways that lead to cascades which in turn may influence the transcriptional activity and function of various proteins including CAMTA1. The specific functional mechanisms by which these activators operate vary significantly. For example, forskolin acts by increasing intracellular cAMP, which in turn can activate PKA and subsequently affect transcription factors involved in CAMTA1 regulation.
Calcium ionophores like A23187 and Ionomycin directly increase intracellular calcium levels, a crucial second messenger in numerous signaling pathways, and can enhance the function of CAMTA1 through its calmodulin-binding domain. Lastly, PMA, as a PKC activator, might alter the phosphorylation status of proteins that interact with or regulate CAMTA1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
BAPTA is a selective calcium chelator used to buffer calcium concentrations in biological research. By tightly controlling intracellular calcium levels, BAPTA could indirectly modulate the activation of CAMTA1 by affecting the binding of calmodulin to calcium, which is a prerequisite for CAMTA1 activation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions through L-type calcium channels. This inhibition may lead to an upregulation of intracellular calcium stores being released, potentially indirectly increasing the activation of calmodulin and subsequently CAMTA1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore known to transport calcium across cellular membranes. By increasing intracellular calcium concentration, A23187 could enhance calmodulin activation, which in turn might activate CAMTA1 through its calmodulin-binding domain. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels within the cell. Elevated cAMP may lead to activation of protein kinase A (PKA), which can phosphorylate various cellular targets, potentially influencing transcription factors that indirectly upregulate the expression of CAMTA1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore which raises intracellular calcium levels. Calcium signaling is critical for the activation of numerous cellular processes, and since CAMTA1 has a calmodulin-binding domain, increased calcium/calmodulin levels may enhance CAMTA1's DNA-binding activity. | ||||||