Calregulin Activators
Common Calregulin Activators include, but are not limited to Thapsigargin CAS 67526-95-8, Tunicamycin CAS 11089-65-9, Dexamethasone CAS 50-02-2, Brefeldin A CAS 20350-15-6 and Forskolin CAS 66575-29-9.
Calregulin, also known as calreticulin, is an evolutionarily conserved, multifunctional protein predominantly found within the endoplasmic reticulum (ER) of cells. It plays essential roles in various cellular processes, including calcium homeostasis, protein folding, and quality control of newly synthesized glycoproteins. Acting as a molecular chaperone, calregulin ensures that proteins within the ER achieve their correct conformational structures, preventing misfolded proteins from advancing through the secretory pathway. Moreover, its ability to bind calcium ions aids in maintaining calcium balance, a critical factor for various cellular signaling cascades and physiological functions.
The chemical class of Calregulin Activators are compounds specifically formulated to amplify the expression or functional activity of calregulin. By enhancing calregulin's actions, these activators can potentiate its role in protein folding and quality control, thereby ensuring efficient protein processing within the ER. This can be particularly relevant in conditions where there's an influx of nascent proteins that require proper folding, or in situations where cellular stress might disrupt protein homeostasis. Furthermore, by modulating calregulin's calcium-binding activity, these activators can have a broader impact on intracellular calcium dynamics, influencing various calcium-dependent cellular processes. In research settings, Calregulin Activators serve as invaluable tools, allowing scientists to delve deeper into the multifaceted roles of calregulin in cellular physiology, ER functions, and beyond.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, leading to ER stress. Increased Calregulin expression might be a response to misfolded protein accumulation in the ER. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, might influence the ER's protein folding environment and consequently affect the expression of chaperones like Calregulin. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus structure and function, leading to ER stress. This could induce Calregulin expression as a compensatory response to the ER stress. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by increasing cAMP levels, might modulate various cellular processes, including the ER stress response, potentially influencing Calregulin expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine's broad kinase inhibitory activity can affect multiple cellular pathways. This could potentially lead to Calregulin upregulation as a cellular response to altered signaling. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
As a CDK inhibitor, roscovitine might affect the cell cycle and consequently the ER's protein folding environment, leading to changes in Calregulin expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, by inhibiting mTOR signaling, might modulate protein synthesis rates, leading to potential changes in the ER environment and Calregulin expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K signaling, potentially affecting multiple cellular responses, including the ER stress response, which could influence Calregulin expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially affecting cellular responses to stress, which might influence the expression of ER chaperones like Calregulin. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, by inhibiting JNK, might modulate cellular responses to stress and thus influence the expression of proteins like Calregulin in the ER. | ||||||