CACHD1 Inhibitors
CACHD1 inhibitors encompass a diverse range of chemical compounds that converge on the common outcome of diminishing the adhesive functions of the calcium-dependent adhesion molecule, CACHD1. L-Carnitine orotate, by serving as a precursor for IP3, indirectly leads to the perturbation of intracellular calcium balance, which is critical for the adhesive functions of CACHD1. On a similar note, the use of Marimastat stifles the dynamic remodeling of the extracellular matrix through its inhibition of MMPs, thereby stabilizing the microenvironment in which CACHD1 operates and diminishing its role in cell motility. Inhibition of the PI3K signaling pathway by LY 294002 results in attenuated AKT signaling, which is imperative for the regulation of cell survival and adhesion, thus indirectly decreasing the activation of CACHD1 in these processes. Gö 6976 and SB 431542 further contribute to this inhibition by targeting the PKC and CK1 enzymes, respectively, disrupting the signaling pathways that would otherwise facilitate cellular adhesion mechanisms involving CACHD1.
Additionally, Forskolin's action in raising cAMP levels, and the subsequent activation of PKA, can lead to an altered adhesion landscape, negatively impacting CACHD1's function. The small GTPase Rac1, pivotal for actin reorganization and cell spreading, is targeted by NSC 23766, thereby interfering with the cytoskeletal rearrangements essential for CACHD1's role. PD 98059 and Y-27632, which inhibit the MEK and ROCK pathways respectively, alter the signaling milieu to one less conducive for CACHD1-mediated cell-cell adhesion. Myosin II ATPase activity, crucial for cytoskeletal contractility and cell motility, is hindered by Blebbistatin, further reducing the adhesive and migratory capacities where CACHD1 might be implicated. Collectively, these inhibitors orchestrate a multifaceted downregulation of the functional activity of CACHD1, emphasizing the intricacies of cellular adhesion and the potential points of intervention to diminish the role of CACHD1 in these processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of Myosin Light Chain Kinase (MLCK) which is involved in cytoskeletal reorganization. By inhibiting MLCK, the cytoskeletal changes necessary for CACHD1-mediated cell adhesion and motility are diminished, leading to the functional inhibition of CACHD1's role in these processes. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor. MMPs are involved in the degradation of the extracellular matrix, a process that is crucial for cell migration and adhesion. By inhibiting MMPs, Marimastat indirectly diminishes the functional activity of CACHD1 by stabilizing the extracellular matrix and reducing cell motility. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This compound is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K is involved in the AKT signaling pathway, which can regulate cell survival and adhesion. Inhibition of PI3K by LY 294002 leads to a decreased AKT signaling, diminishing the downstream signaling that might otherwise lead to the activation of CACHD1 in cell adhesion. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö 6976 is a protein kinase C (PKC) inhibitor. Given that PKC can influence cell adhesion and motility, inhibition by Gö6976 could diminish the functional activities of CACHD1 by reducing PKC-mediated signaling pathways that support cellular adhesion mechanisms where CACHD1 might be involved. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 is a casein kinase 1 (CK1) inhibitor. CK1 is implicated in Wnt signaling, which modulates cell-to-cell adhesion. By inhibiting CK1, D4476 can diminish the signaling pathways that may indirectly enhance the function of CACHD1 in cell adhesion and migration. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels, which can then activate PKA. PKA phosphorylates various targets that can modulate cellular adhesion. Elevated cAMP levels can, therefore, lead to changes in cell adhesion dynamics, potentially diminishing the adhesive functions of CACHD1. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 inhibits Rac1, a small GTPase involved in cytoskeletal reorganizations necessary for cell adhesion. By inhibiting Rac1, this compound would lead to a functional inhibition of CACHD1 by preventing the actin cytoskeletal rearrangements and cell spreading processes in which CACHD1 may play a role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a MEK inhibitor that blocks the MAPK/ERK pathway. The MAPK/ERK pathway is involved in cell proliferation and differentiation, which are processes that can influence cell adhesion. Inhibition of this pathway by PD 98059 diminishes the potential for CACHD1 to function in cell-cell adhesion during these cellular processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. The Rho/ROCK pathway plays a significant role in actin cytoskeleton organization. By inhibiting ROCK, this compound indirectly diminishes the functional activity of CACHD1 by altering the cytoskeletal dynamics that underlie the adhesion and migration processes where CACHD1 is potentially involved. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin is an inhibitor of myosin II ATPase activity. Myosin II is essential for cytoskeletal contractility and cell motility. By inhibiting myosin II, blebbistatin can diminish the cellular processes that facilitate cell adhesion and migration. | ||||||