Date published: 2025-10-7

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CA XII Inhibitors

CA XII inhibitors are a class of compounds primarily characterized by their ability to modulate the activity of the enzyme carbonic anhydrase XII. This enzyme, part of the larger family of carbonic anhydrases, is integral in catalyzing the reversible hydration of carbon dioxide. Inhibitors of CA XII can act directly, typically by binding to the active site of the enzyme, or indirectly, by influencing associated cellular pathways. Direct inhibitors often belong to the sulfonamide class, such as Acetazolamide and Methazolamide. These compounds are structurally equipped to interact with the zinc ion in the active site of carbonic anhydrases, thereby diminishing the enzyme's catalytic efficiency. The structural similarity among various carbonic anhydrase isoforms allows these inhibitors, initially designed for other isoforms like CA II, to potentially affect CA XII. On the other hand, indirect inhibitors work by modulating pathways related to CA XII's function. For example, Celecoxib, a COX-2 inhibitor, can influence carbonic anhydrase activity by altering inflammation pathways, which are closely linked to the physiological roles of carbonic anhydrases. Similarly, diuretics like Hydrochlorothiazide impact the renal system, which in turn can influence the activity of carbonic anhydrases, including CA XII.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dorzolamide Hydrochloride

130693-82-2sc-207596
10 mg
$186.00
(1)

Dorzolamide Hydrochloride is characterized by its distinctive sulfonamide framework, which facilitates specific hydrogen bonding interactions with adjacent molecules. This compound exhibits notable solubility in polar environments, attributed to its charged functional groups. The presence of the hydrochloride moiety enhances its ionic character, promoting rapid diffusion in aqueous systems. Furthermore, its stereochemistry plays a crucial role in determining its reactivity and interaction dynamics in complex chemical environments.

Acetazolamide

59-66-5sc-214461
sc-214461A
sc-214461B
sc-214461C
sc-214461D
sc-214461E
sc-214461F
10 g
25 g
100 g
250 g
500 g
1 kg
2 kg
$79.00
$174.00
$425.00
$530.00
$866.00
$1450.00
$2200.00
1
(1)

A sulfonamide that inhibits carbonic anhydrases by binding to the zinc ion in the active site, decreasing activity.

Methazolamide

554-57-4sc-235615
1 g
$92.00
3
(1)

Another sulfonamide, similar to Acetazolamide, with a longer duration of action, inhibiting carbonic anhydrase activity.

Dorzolamide

120279-96-1sc-337687
1 g
$960.00
2
(0)

Topically active sulfonamide and carbonic anhydrase inhibitor, it specifically targets CA II but might also affect CA XII.

Brinzolamide

138890-62-7sc-481649
10 mg
$264.00
(0)

A sulfonamide carbonic anhydrase inhibitor, primarily targeting CA II, but potentially affecting other isoforms.

Topiramate

97240-79-4sc-204350
sc-204350A
10 mg
50 mg
$105.00
$362.00
(1)

A broader-spectrum drug that inhibits carbonic anhydrase among other mechanisms, potentially affecting CA XII.

(RS)-(±)-Sulpiride

15676-16-1sc-205494
100 mg
$69.00
(0)

Though primarily an antipsychotic, it can indirectly affect carbonic anhydrase activity via dopaminergic pathways.

Hydrochlorothiazide

58-93-5sc-207738
sc-207738A
sc-207738B
sc-207738C
sc-207738D
5 g
25 g
50 g
100 g
250 g
$54.00
$235.00
$326.00
$551.00
$969.00
(0)

A diuretic that can indirectly affect carbonic anhydrase activity through renal system modulation.

Bumetanide (Ro 10-6338)

28395-03-1sc-200727
sc-200727A
1 g
5 g
$107.00
$224.00
9
(1)

A diuretic that can indirectly affect carbonic anhydrase, including CA XII, by influencing ion transport.