C5orf49_1700001L19Rik Activators
C5orf49 Activators are a collection of chemical compounds that serve to enhance the functional activity of C5orf49 through interactions with various cellular signaling pathways. Forskolin and IBMX, for instance, contribute to the increased activity of C5orf49 by elevating intracellular cAMP levels, which in turn activates PKA, a kinase that may phosphorylate and thus activate C5orf49 or its associated pathways. PMA acts through the PKC pathway, leading to potential phosphorylation events that can impact signaling cascades involving C5orf49, while A23187, through increased intracellular calcium, activates calcium-dependent mechanisms that may indirectly enhance C5orf49 activity. Spermine, through its role in modulating ion channels, may influence cellular signaling in a manner that leads to C5orf49 activation.
C5orf49 Activators encompass a range of chemical compounds that indirectly enhance the functional activity of C5orf49 by modulating various signaling pathways. Forskolin raises cAMP levels, which activates PKA, a kinase that could phosphorylate substrates involved in the activation of C5orf49. Concurrently, IBMX prevents cAMP and cGMP degradation, sustaining their levels and further amplifying PKA signaling towards pathways involving C5orf49. PMA's activation of PKC leads to phosphorylation events that could enhance C5orf49's functional role within its respective pathways. A23187 and Thapsigargin both manipulate intracellular calcium levels, A23187 by acting as a calcium ionophore and Thapsigargin by inhibiting the SERCA pump, each triggering calcium-dependent signaling cascades that may ultimately enhance the activity of C5orf49. Spermine, by modulating ion channel function, could influence intracellular signaling in a way that enhances C5orf49 activity, while the tyrosine kinase inhibitor Genistein reduces competitive phosphorylation events, potentially favoring the activation of C5orf49.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increase in cAMP levels can subsequently activate PKA signaling pathways that may enhance the activity of C5orf49. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate multiple target proteins. PKC-mediated phosphorylation can lead to the activation of pathways that indirectly enhance the activity of C5orf49. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially leading to the activation of pathways that enhance C5orf49 function. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that can modulate various ion channels and has been shown to influence cellular signaling. By affecting these cellular processes, spermine could indirectly enhance the activity of C5orf49 through modulation of signal transduction pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can potentiate signaling pathways not directly dependent on tyrosine kinase activity, which may include pathways that enhance C5orf49 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter downstream signaling, including the Akt pathway. By inhibiting PI3K, LY294002 may enhance the activity of C5orf49 through alternative pathways not reliant on PI3K-Akt signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor that can suppress the MAPK/ERK pathway, potentially leading to the activation of alternative pathways or compensation mechanisms that enhance C5orf49 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which can shift cellular signaling dynamics to favor pathways not directly involving p38 MAPK, potentially leading to the enhanced activity of C5orf49. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a broad-spectrum kinase inhibitor with antioxidant properties. By inhibiting certain kinases, EGCG may indirectly enhance the activity of C5orf49 through alternative signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor which leads to an increase in cytosolic calcium. The elevated calcium levels can activate calcium-dependent proteins and pathways, potentially leading to enhanced C5orf49 activity. | ||||||