C5orf33 Activators
C5orf33 is an enzyme that plays a crucial role in the regulation of cellular NADP+ levels by catalyzing the phosphorylation of NAD+ to NADP+. The activity of this enzyme can be enhanced by increasing the availability of its substrate, NAD+. Precursors to NAD+, as well as compounds that upregulate the NAD+ salvage pathway, effectively boost the levels of NAD+ within cells, thereby facilitating the enzymatic action of C5orf33. Additionally, activators of AMP-activated protein kinase (AMPK) contribute to this process by stimulating the biosynthesis of NAD+, providing a larger pool of substrate for C5orf33 to act upon. The consequent rise in NADP+ production is critical for various anabolic processes, including fatty acid, nucleotide, and cholesterol synthesis.
Furthermore, certain compounds that influence mitochondrial biogenesis and function can indirectly promote the activity of C5orf33 by increasing the cellular demand for NADP+. This is due to the enzyme's location within mitochondria, where it fulfills the need for NADP+, necessary for the redox balance and proper functioning of the organelle. Compounds that modulate intracellular calcium levels also play a role in activating C5orf33, potentially via calcium/calmodulin-dependent kinases that can phosphorylate and activate mitochondrial enzymes. By ensuring ample NADP+ supply, C5orf33 is central to maintaining cellular redox states and metabolism by catalyzing the conversion of NAD+ to NADP+. The functional activity of C5orf33 can be enhanced through the elevation of intracellular NAD+ levels, which serves as the substrate for the enzyme. This elevation can be achieved by compounds that either supply NAD+ directly or promote its synthesis through activation of NAD+ biosynthetic pathways. For instance, compounds that activate sirtuins or AMPK can lead to a higher NAD+ turnover or biosynthesis, respectively. This upsurge in NAD+ levels is a direct driver for C5orf33, enabling it to produce more NADP+, which is indispensable for anabolic reactions and redox balance in the cell, especially within mitochondria.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
This compound serves as a precursor to NAD+, which is a substrate for C5orf33 (NAD kinase 2, mitochondrial). The enzyme catalyzes the phosphorylation of NAD+ to generate NADP+, thus an increase in NAD+ levels directly enhances the activity of C5orf33. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This compound increases intracellular calcium levels, which can activate calcium/calmodulin-dependent kinases. These kinases can phosphorylate various targets, including enzymes like C5orf33, potentially increasing its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase that requires NAD+ to function. The activation of SIRT1 can lead to an increased demand for NAD+, which in turn can stimulate the activity of C5orf33 to replenish NADP+ levels. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Has been shown to increase NAD+ levels through modulation of AMPK and SIRT1 pathways. Elevated NAD+ levels would stimulate C5orf33 activity to maintain cellular NADP+ homeostasis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
This compound activates AMPK, which enhances NAD+ biosynthesis through upregulation of the NAD+ salvage pathway. Higher NAD+ availability can enhance C5orf33 activity due to increased substrate availability. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid has been shown to activate AMPK. Activated AMPK can increase NAD+ biosynthesis thereby promoting C5orf33 activity through elevated substrate levels. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
This compound is known to influence mitochondrial biogenesis and function, which could lead to an increased demand for NADP+, thereby stimulating C5orf33 activity to meet this demand. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy and mitochondrial health, potentially increasing the demand for NADP+ in mitochondrial maintenance processes, which would activate C5orf33 to supply the required NADP+. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can lead to increased NAD+ production. The increased NAD+ availability would, in turn, stimulate C5orf33 activity to generate NADP+. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK, enhancing NAD+ biosynthesis. The resulting increase in NAD+ levels would directly stimulate C5orf33 to produce NADP+. | ||||||