C330005M16Rik Activators
Acp7, or tartrate-resistant acid phosphatase 7, is a key player in cellular processes, predicted to possess acid phosphatase activity and metal ion binding ability. As an ortholog of the human ACP7, it likely shares functional characteristics associated with acid phosphatases. The activation of Acp7 is governed by various chemical compounds that directly or indirectly modulate its enzymatic activity and cellular functions. Acp7's direct activators include compounds like calcitriol, zinc chloride, and aluminum chloride. Calcitriol directly engages with the vitamin D receptor, enhancing Acp7's acid phosphatase activity crucial for cellular processes. Zinc and aluminum chlorides directly influence Acp7 through metal ion binding, further highlighting the importance of metal ions in regulating its catalytic function. Additionally, Acp7 can be indirectly activated by compounds like citric acid, parathyroid hormone (PTH), and estradiol. Citric acid influences extracellular pH, impacting Acp7's acid phosphatase activity in the extracellular region. PTH and estradiol, through their respective signaling pathways, modulate Acp7 expression and activity, contributing to cellular processes associated with acid phosphatase function.
Other indirect activators, such as phosphate, retinoic acid, prostaglandin E2, ferrous sulfate, vitamin C, and 1,25-dihydroxycholecalciferol, influence Acp7 through various mechanisms. These include substrate binding, transcriptional regulation, signaling pathway modulation, and redox status changes. The nuanced interplay between these chemicals and Acp7 underscores the complexity of its activation and its involvement in diverse cellular processes. In conclusion, Acp7's activation is a finely tuned process influenced by an array of chemical compounds, highlighting its significance in cellular functions associated with acid phosphatase activity. Understanding these mechanisms sheds light on the intricate regulation of Acp7 and its potential impact on cellular processes requiring tartrate-resistant acid phosphatase function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
A biologically active form of vitamin D that directly activates Acp7 by binding to the vitamin D receptor. This complex translocates to the nucleus, modulating gene expression. Acp7, being a tartrate-resistant acid phosphatase, responds to calcitriol, leading to enhanced acid phosphatase activity crucial for cellular processes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
A metal ion that directly activates Acp7 by binding to its metal ion binding site. Zinc chloride enhances the metal ion binding activity of Acp7, influencing its catalytic function. The activation of Acp7 by zinc chloride is essential for its role as a tartrate-resistant acid phosphatase, contributing to cellular processes associated with this enzymatic activity. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
An organic acid that indirectly activates Acp7 by influencing extracellular pH. Citric acid modulates the extracellular environment, impacting the activity of Acp7, which functions in the extracellular region. Changes in pH induced by citric acid indirectly enhance Acp7's acid phosphatase activity, playing a role in cellular processes where tartrate-resistant acid phosphatase function is crucial. | ||||||
Sodium phosphate | 7601-54-9 | sc-251041 sc-251041A | 25 g 500 g | $41.00 $46.00 | ||
An inorganic salt that directly activates Acp7 by serving as a substrate for its acid phosphatase activity. Phosphate directly engages with the active site of Acp7, enhancing its catalytic function. The activation of Acp7 by phosphate is crucial for cellular processes where tartrate-resistant acid phosphatase activity is involved in phosphate metabolism and other relevant functions. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
A steroid hormone that indirectly activates Acp7 by influencing hormonal signaling pathways. Estradiol modulates gene expression patterns that impact Acp7 activity. The activation of Acp7 by estradiol is crucial for its role as a tartrate-resistant acid phosphatase, contributing to cellular processes associated with hormonal regulation and acid phosphatase activity. | ||||||
Aluminum chloride anhydrous | 7446-70-0 | sc-214528 sc-214528B sc-214528A | 250 g 500 g 1 kg | $92.00 $97.00 $133.00 | ||
A metal ion that directly activates Acp7 by binding to its metal ion binding site. Aluminum chloride enhances the metal ion binding activity of Acp7, influencing its catalytic function. The activation of Acp7 by aluminum chloride is essential for its role as a tartrate-resistant acid phosphatase, contributing to cellular processes associated with this enzymatic activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A vitamin A derivative that indirectly activates Acp7 by modulating gene expression. Retinoic acid influences Acp7 activity through transcriptional regulation. The activation of Acp7 by retinoic acid is crucial for its role as a tartrate-resistant acid phosphatase, contributing to cellular processes associated with vitamin A metabolism and acid phosphatase activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
A lipid mediator that indirectly activates Acp7 through the EPAC pathway. Prostaglandin E2 stimulates EPAC, leading to signaling cascades that influence Acp7 activity. The activation of Acp7 by prostaglandin E2 is essential for its role as a tartrate-resistant acid phosphatase, contributing to cellular processes associated with lipid signaling and acid phosphatase activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
An antioxidant that indirectly activates Acp7 by influencing extracellular redox status. Vitamin C modulates the redox environment, impacting Acp7 activity. Changes in redox status induced by vitamin C indirectly enhance Acp7's acid phosphatase activity, playing a role in cellular processes where tartrate-resistant acid phosphatase function is crucial. | ||||||