C19orf24 Inhibitors
C19orf24 inhibitors encompass a diverse set of chemical compounds that target various cellular pathways and processes which are either directly or indirectly associated with the activity and function of C19orf24. Kinase inhibitors like staurosporine exert their effects by inhibiting the kinase activity that is paramount for the phosphorylation and subsequent activation of numerous proteins, potentially including C19orf24. By impeding this phosphorylation, staurosporine can lead to a decrease in C19orf24 activity. Similarly, LY294002 operates by specifically obstructing PI3K, which is crucial for AKT signaling, a pathway that might affect the stability or localization of C19orf24, thus indirectly inhibiting its functionality. This inhibition could result in lesser phosphorylation of substrates required for C19orf24's activation or stabilization.
The functional mechanisms of other compounds, such as rapamycin, also indirectly impact C19orf24 activity. Rapamycin's inhibition of the mTOR pathway disrupts protein synthesis and other survival pathways that could be essential for C19orf24's role within the cell. Inhibition by rapamycin might lead to a reduction in cellular resources necessary for C19orf24 function. Furthermore, the glycolysis inhibitor 2-Deoxy-D-glucose can indirectly affect C19orf24 by reducing the cellular energy pool, which is vital for the activity of numerous proteins. On the other hand, Alisertib targets Aurora kinase A, which is involved in the cell cycle. Disruption of the cell cycle can indirectly affect proteins like C19orf24, which may be regulated in a cell cycle-dependent manner. The MEK inhibitors U0126 and PD0325901 may lead to decreased activity of the MAPK/ERK pathway, which is known to be involved in a wide array of cellular functions, including those that could impinge upon C19orf24 functionality. By dampening this pathway, these inhibitors could reduce the activity of C19orf24 by limiting the signaling that contributes to its proper function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent protein kinase inhibitor that targets a wide range of kinases. C19orf24 activity is kinase-dependent; thus, staurosporine indirectly inhibits C19orf24 by reducing the phosphorylation state of its kinase-dependent activation sites. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can downregulate AKT signaling, which may be necessary for the stability or localization of C19orf24, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can disrupt downstream signaling necessary for protein synthesis and survival pathways that C19orf24 may rely on, indirectly leading to its functional inhibition. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glucose analog that inhibits glycolysis. As C19orf24 is potentially linked to cellular metabolism, the inhibition of glycolysis can indirectly inhibit C19orf24 by depleting its energy sources. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora kinase A inhibitor. Aurora kinases are involved in cell cycle regulation. Inhibition of Aurora kinase A can disrupt cell cycle progression, indirectly affecting proteins like C19orf24 that may be regulated during the cell cycle. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A MEK1/2 inhibitor that impairs the MAPK/ERK pathway. Because C19orf24 may be involved in signaling pathways modulated by MAPK/ERK, U0126 could indirectly inhibit C19orf24 by altering the pathway's activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor that leads to increased cytosolic calcium levels and can induce ER stress. ER stress has been linked to the inhibition of various proteins, potentially including C19orf24. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, inducing cellular stress and potentially leading to the inhibition of proteins like C19orf24. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that changes chromatin structure and gene expression. By altering gene expression, Trichostatin A could indirectly inhibit C19orf24 if its function depends on the expression of specific genes. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
An inhibitor of the Hedgehog signaling pathway. C19orf24 may be indirectly inhibited if it is part of a signaling cascade or cellular process that is regulated by the Hedgehog pathway. | ||||||