C130060K24Rik Activators
Qrfprl, a gene predicted to enable G protein-coupled receptor activity, plays a crucial role in various structures, including the brain, cardiovascular system, cranium, limb, and urinary system. Its orthologous relationship to human QRFPR, specifically the pyroglutamylated RFamide peptide receptor, suggests conserved functionality in signaling cascades mediated by G protein-coupled receptors. Qrfprl's involvement in the G protein-coupled receptor signaling pathway signifies its key role in cellular communication and responsiveness to extracellular signals.
The activation of Qrfprl involves intricate interactions with various chemicals, each influencing specific biochemical or cellular pathways. For instance, Forskolin activates Qrfprl through the cAMP-PKA pathway, while Angiotensin II engages the Angiotensin II type 1 receptor, initiating G protein-coupled signaling. Dopamine, serotonin, and substance P activate Qrfprl through their respective receptors, showcasing the diversity of neurotransmitter-mediated pathways. Other activators, such as histamine, prostaglandin E2, and endothelin-1, exert their effects through specific receptors, contributing to the intricate network of Qrfprl activation. Adenosine and acetylcholine, acting as neurotransmitters, impact Qrfprl through G protein-coupled signaling pathways, further highlighting the gene's responsiveness to various extracellular cues. Bradykinin, an endogenous peptide, activates Qrfprl through bradykinin receptors, linking the gene to cardiovascular and urinary system regulation. Understanding the nuanced mechanisms of Qrfprl activation sheds light on its role in diverse physiological processes and provides a foundation for future investigations into the intricate world of G protein-coupled receptor signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II, an endogenous peptide, activates Qrfprl through the Angiotensin II type 1 receptor. Binding to this receptor triggers G protein-coupled signaling, directly impacting Qrfprl activity. This chemical influences the Angiotensin II signaling pathway, leading to Qrfprl activation in structures like the cardiovascular system and urinary system. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol, a muscarinic acetylcholine receptor agonist, activates Qrfprl through G protein-coupled signaling. Binding to muscarinic receptors induces intracellular cascades, influencing Qrfprl activity. This chemical directly engages muscarinic receptors, modulating the cholinergic signaling pathway and leading to Qrfprl activation in structures such as the brain and cardiovascular system. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, a neurotransmitter, activates Qrfprl through dopamine receptors, engaging G protein-coupled signaling. This chemical directly influences dopaminergic pathways, impacting Qrfprl activity in structures like the brain and cardiovascular system. Dopamine receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin, a neurotransmitter, activates Qrfprl via serotonin receptors, engaging G protein-coupled signaling. This chemical directly influences serotonergic pathways, impacting Qrfprl activity in structures like the brain and cardiovascular system. Serotonin receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
Substance P | 33507-63-0 | sc-201169 | 1 mg | $56.00 | ||
Substance P, a neuropeptide, activates Qrfprl through neurokinin receptors, initiating G protein-coupled signaling. This chemical directly influences the neurokinin signaling pathway, impacting Qrfprl activity in structures like the brain and cardiovascular system. Neurokinin receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine activates Qrfprl via histamine receptors, engaging G protein-coupled signaling. This chemical directly influences histaminergic pathways, impacting Qrfprl activity in structures like the brain and cardiovascular system. Histamine receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 activates Qrfprl through EP receptors, initiating G protein-coupled signaling. This chemical directly influences prostaglandin pathways, impacting Qrfprl activity in structures like the brain and cardiovascular system. EP receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, a nucleoside, activates Qrfprl through adenosine receptors, initiating G protein-coupled signaling. This chemical directly influences adenosinergic pathways, impacting Qrfprl activity in structures like the brain and cardiovascular system. Adenosine receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin, an endogenous peptide, activates Qrfprl through bradykinin receptors, initiating G protein-coupled signaling. This chemical directly influences bradykinin pathways, impacting Qrfprl activity in structures like the cardiovascular system and urinary system. Bradykinin receptor activation induces intracellular cascades, ultimately leading to Qrfprl activation and subsequent cellular responses. | ||||||