C11orf24 Inhibitors
C11orf24 inhibitors are a diverse group of compounds that indirectly decrease the activity of C11orf24 through various mechanisms affecting the signaling pathways with which C11orf24 is associated. PI3K inhibitors such as Wortmannin and LY294002 suppress the PI3K/AKT pathway, leading to reduced activation of downstream proteins like C11orf24. Similarly, MEK inhibitors like PD98059 and U0126, by preventing the activation of ERK1/2, potentially reduce the activity of C11orf24 if it is a downstream target of the MEK/ERK signaling cascade. Additionally, the p38 MAPK inhibitor SB203580 and the JNK inhibitor SP600125 can inhibit C11orf24 function by suppressing p38 and JNK signaling, respectively, if these kinases are upstream regulators of the protein.
Dasatinib and Imatinib can inhibit the activity of various tyrosine kinases, which may affect C11orf24 if it is regulated by tyrosine kinase signaling pathways. Bortezomib, a proteasome inhibitor, could result in an accumulation of misfolded proteins and affect the stability or turnover of C11orf24 if it is subject to regulation by the ubiquitin-proteasome system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
PIK-75 is a selective PI3K inhibitor that suppresses the PI3K/AKT/mTOR signaling pathway. Since C11orf24 is involved in this pathway, PIK-75 can inhibit C11orf24 by reducing AKT phosphorylation, thus preventing its activation and downstream signaling that could lead to C11orf24 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key protein downstream of PI3K/AKT signaling. C11orf24, being part of this pathway, can be inhibited as rapamycin leads to the deactivation of mTORC1, which is required for the full activation of proteins regulated by mTOR, including C11orf24. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a specific inhibitor of the FGFR tyrosine kinase which is involved in the regulation of several intracellular signaling cascades. Inhibition of FGFR could alter the downstream signaling that may include C11orf24, leading to its functional inhibition. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $92.00 $281.00 | 6 | |
LY333531 is a selective inhibitor of PKC beta. If C11orf24 is regulated by PKC beta-mediated signaling for its activation, inhibition of PKC beta by LY333531 would result in decreased C11orf24 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Src family kinases. By blocking Src kinase activity, PP2 may reduce the phosphorylation and subsequent activation of proteins that interact with or regulate C11orf24, leading to its inhibition. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 inhibits GSK-3β, a kinase involved in numerous cellular functions. If C11orf24's activity is dependent on GSK-3β mediated signaling, inhibition by SB216763 would result in a decrease in C11orf24 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins and potentially affect protein turnover. If C11orf24 is regulated by ubiquitination, its activity could be indirectly inhibited by bortezomib through altered protein degradation pathways. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a pan-PKC inhibitor. If C11orf24 is activated by PKC-dependent signaling pathways, Go6983 can inhibit these pathways, thereby decreasing C11orf24 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. If C11orf24 operates downstream of JNK signaling, its activity would be inhibited by SP600125 through the prevention of JNK-mediated activation processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that prevents AKT activation. Inhibition of PI3K/AKT signaling by LY294002 could lead to the downregulation of C11orf24 if it is an AKT substrate or its activity is AKT-dependent. | ||||||