c-Jun Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132, known as Z-Leu-Leu-Leu-CHO, is a potent inhibitor that selectively targets the proteasome, interfering with the ubiquitin-proteasome system. This compound exhibits a high affinity for the proteasome's catalytic sites, leading to the stabilization of misfolded proteins. Its unique interaction dynamics result in altered cellular homeostasis, influencing pathways related to stress responses and apoptosis. The compound's ability to modulate protein turnover significantly impacts transcriptional regulation, particularly affecting c-Jun activity. | ||||||
Sphingosylphosphorylcholine, D-erythro | 1670-26-4 | sc-201384 | 10 mg | $408.00 | 1 | |
Sphingosylphosphorylcholine, D-erythro, is a bioactive sphingolipid that engages in intricate signaling pathways, particularly influencing cellular responses to stress. It interacts with specific receptors, triggering downstream effects that modulate gene expression and cellular proliferation. This compound exhibits unique kinetics in membrane dynamics, facilitating lipid raft formation and altering membrane fluidity. Its role in cell signaling is pivotal, impacting various physiological processes through distinct molecular interactions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a powerful activator of the Protein Kinase C (PKC) pathway, leading to the activation of MAPK pathway and ultimately c-Jun expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
H2O2, as a reactive oxygen species (ROS), can stimulate the MAPK pathway and upregulate c-Jun expression, potentially as part of the cellular response to oxidative stress. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramides are known to activate the MAPK pathway, leading to the upregulation of c-Jun, potentially as part of the cellular response to stress. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a chemotherapy drug, can cause DNA damage, leading to the activation of the MAPK pathway and upregulation of c-Jun, potentially as part of the DNA damage response. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Arsenite can cause oxidative stress, which activates the MAPK pathway and leads to the upregulation of c-Jun, potentially as part of the cellular response to stress. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone, by inhibiting mitochondrial complex I, can increase ROS production, which activates the MAPK pathway and upregulates the expression of c-Jun. | ||||||