c-IAP 1 Inhibitors

c-IAP1 inhibitors are chemical compounds that directly influence the function of c-IAP1, a protein known to be an inhibitor of apoptosis. Inhibitors such as SM-164, GDC-0152, LBW242, Birinapant, Embelin, AT406, HSP990, 17-AAG, LCL161, Debio 1143, TL32711, and YM155 can lead to the decreased functional activity of c-IAP1 through specific signaling pathways or biological processes that it is directly involved in.

For instance, SM-164, GDC-0152, LBW242, Birinapant, AT406, LCL161, Debio 1143, and TL32711 are IAP antagonists that bind to the BIR3 domains of c-IAP1, promoting its rapid degradation and thus inhibiting its functional activity. Embelin and YM155, on the other hand, inhibit XIAP and survivin respectively, both of which can stabilize c-IAP1, leading to decreased c-IAP1 stability and functional activity. Similarly, HSP990 and 17-AAG are HSP90 inhibitors, and since Hsp90 can stabilize c-IAP1, the inhibition of Hsp90 can lead to decreased c-IAP1 stability and functional activity. In summary, these c-IAP1 inhibitors influence the protein's functionality by affecting the specific biochemical or cellular pathways in which c-IAP1 plays a role.