BZW2 Activators
BZW2 Activators encompass a range of chemical compounds that indirectly encourage the functional activityBZW2 Activators encompass a range of chemical compounds that indirectly encourage the functional activity of BZW2 through various signal transduction pathways, particularly those linked to the regulation of translation initiation. Forskolin, through the elevation of cAMP levels, activates PKA which may influence the phosphorylation state of BZW2 or its associated factors, thereby enhancing BZW2's role in protein synthesis. Ionomycin, a calcium ionophore, increases intracellular calcium that activates calcium-dependent protein kinases potentially affecting BZW2 function. PMA, as an activator of PKC, and Okadaic acid, an inhibitor of protein phosphatases, both lead to enhanced phosphorylation within cellular signaling pathways, which could indirectly enhance BZW2's activity. Anisomycin activates stress-activated protein kinases possibly affecting BZW2's role under stress conditions, while LY294002 and U0126 disrupt PI3K/AKT and MEK/ERK pathways, respectively, potentially modulating BZW2's involvement in translation initiation.
Further influence on BZW2's activity comes from compounds such as SB203580 and Rapamycin, which inhibit p38 MAPK and mTOR, respectively, leading to alterations in signaling pathways that could shift the balance towards mechanisms that enhance BZW2 activity. Epigallocatechin gallate (EGCG), through tyrosine kinase inhibition, may similarly affect signaling pathways, thereby enhancing BZW2's functional role. Staurosporine, despite its broad-spectrum kinase inhibition, may indirectly upregulate BZW2 activity by triggering compensatory signaling pathways. Lastly, Thapsigargin causes a rise in cytosolic calcium, potentially influencing BZW2 activity through calcium-dependent signaling cascades. Collectively, these BZW2 Activators, through their targeted biochemical interactions, facilitate the enhancement of BZW2-mediated functions within the complex network of cellular signaling, without the need for direct activation or increased expression of BZW2.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular levels of cAMP. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various substrates including factors that may interact with BZW2, thereby influencing its activity related to translation initiation control. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent protein kinases. These kinases could then modulate the phosphorylation status of BZW2 or its associated factors, affecting BZW2's role in the initiation of protein synthesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to phosphorylation of proteins that are involved in the signaling pathways that regulate translation initiation, potentially enhancing the functional activity of BZW2 in this process. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases results in increased phosphorylation levels of proteins within the cell, which could indirectly increase the phosphorylation and activation of BZW2-related pathways involved in translation initiation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases like JNK. This activation can lead to the phosphorylation of downstream targets, which may include regulatory proteins that interact with BZW2, thereby potentially enhancing its role in translation initiation under stress conditions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to alterations in the AKT/mTOR signaling pathway. Since mTOR is a key regulator of translation initiation, inhibition of PI3K/AKT pathway can modulate the activities of translation initiation factors, possibly affecting BZW2's function in this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, components of the MAPK/ERK pathway. By inhibiting MEK, U0126 may indirectly influence the activity of BZW2 by modulating the signaling pathways that control the initiation of protein synthesis, as ERK can phosphorylate and affect various proteins involved in this process. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can alter the signaling dynamics within the cell, potentially affecting pathways that regulate translation initiation. As BZW2 is involved in the regulation of translation initiation, the inhibition of p38 MAPK might indirectly enhance BZW2's functional activity by shifting signaling towards BZW2-involved pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can disrupt the mTORC1 complex, leading to dephosphorylation of downstream targets that are crucial for cap-dependent translation initiation. By inhibiting one branch of the mTOR pathway, rapamycin may lead to a compensatory activation of other pathways that enhance the activity of BZW2 in translation initiation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that can affect multiple signaling pathways, including those that regulate protein synthesis. By inhibiting certain kinases, EGCG may modulate signaling cascades that lead to the activation of BZW2, enhancing its functional role in translation initiation. | ||||||