BUP-1 Activators
BUP-1 Activators are chemical compounds that enhance the functional activity of BUP-1 through specific cellular and biochemical pathways. Acetylcholine, by engaging nicotinic acetylcholine receptors, facilitates an influx of calcium ions crucial for the activation of BUP-1, which plays a role in calcium-dependent cellular processes in muscle tissue. Ryanodine, by modulating the release of calcium from the sarcoplasmic reticulum, also impacts the activity of BUP-1, given its role in calcium signaling. PIP2 and its downstream product, DAG, function within the PLC pathway to elevate intracellular calcium levels and activate PKC, respectively, both of which are essential for the phosphorylation events that regulate BUP-1 function. Calmodulin, as a calcium-binding protein, activates various enzymes and proteinsassociated with calcium signaling, thereby enhancing BUP-1's regulatory roles.
The secondary messengers cAMP and cGMP, through their respective kinases PKA and PKG, also play pivotal roles in the regulation of BUP-1 activity. The increased cAMP levels induced by Forskolin activate PKA, which may target BUP-1 or associated proteins for phosphorylation, enhancing BUP-1's role in signaling. Similarly, cGMP levels raised by nitric oxide donors activate PKG, which might also result in the phosphorylation of proteins that modulate the activity of BUP-1. Calcium ionophores such as A23187 and Ionomycin directly increase calcium concentrations within the cell, a critical factor for BUP-1 activity in calcium-dependent processes. Phorbol esters, as activators of PKC, and ATP, through its action on purinergic receptors, are capable of triggering signaling cascades that can result in the enhanced functional activity of BUP-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine binds to ryanodine receptors on the sarcoplasmic reticulum in muscle cells, modulating the release of calcium. By influencing calcium dynamics, ryanodine can enhance the activity of BUP-1, which is involved in calcium-dependent cellular processes. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin is a calcium-binding messenger protein that can interact with various enzymes and other proteins to activate them in a calcium-dependent manner. The binding of calcium to calmodulin can, therefore, enhance BUP-1 activity by facilitating its calcium-mediated regulatory functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium concentration by allowing calcium ions to cross cell membranes. By altering calcium homeostasis, A23187 can enhance BUP-1 activity that is regulated by calcium levels. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
Nitric oxide donors release nitric oxide, which can activate guanylate cyclase and increase cGMP levels, leading to the activation of protein kinase G (PKG). PKG can phosphorylate proteins that modulate calcium channels or signaling, indirectly enhancing BUP-1 activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP is a secondary messenger that activates protein kinase A (PKA). PKA can phosphorylate various proteins, potentially including BUP-1 or proteins that regulate BUP-1's activity, thereby enhancing its function in signaling pathways. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
Phorbol esters activate PKC, which can then phosphorylate target proteins. Through the phosphorylation of BUP-1 or associated proteins, phorbol esters can enhance the activity of BUP-1 in signaling pathways where PKC is involved. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration by transporting calcium ions across cellular membranes. This influx of calcium can enhance BUP-1 activity if BUP-1 is regulated by calcium signaling. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $53.00 | ||
ATP can bind to purinergic receptors, leading to various intracellular signaling events including the activation of ion channels and second messenger pathways. This can enhance BUP-1 activity by modulating the cellular signaling environment. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can enhance the activity of PKA, which may phosphorylate BUP-1 or proteins in pathways involving BUP-1, thereby enhancing its functional activity. | ||||||