BUD31 Activators
BUD31 Activators are chemical compounds that enhance the functional activity of BUD31, a protein involved in the splicing of pre-mRNA within the spliceosome complex. Phosphatidic Acid, through the activation of MAPK, and Sphingosine-1-phosphate, by activating kinases that phosphorylate SR proteins, can enhance BUD31's activity in mRNA processing. These compounds work by promoting phosphorylation events that are essential for the regulation of splicing, where BUD31's role is crucial.
Compounds such as Ionomycin, Forskolin, and Bryostatin 1 manipulate intracellular signaling molecules like calcium, cAMP, and PKC, respectively, to influence the activity of BUD31. Ionomycin increases calcium levels, which may enhance the interaction of BUD31 with calcium-dependent splicing factors, while Forskolin raises cAMP levels, activating PKA which may indirectly enhance the functionof BUD31 by phosphorylating associated splicing factors. Bryostatin 1 activates PKC, which can phosphorylate substrates involved in RNA processing, potentially leading to increased activity of BUD31 in mRNA splicing. Moreover, Epigallocatechin gallate (EGCG) and Caffeine inhibit phosphodiesterases, increasing cAMP and cGMP levels, which activates PKA and PKG, leading to the phosphorylation of splicing factors and potentially enhancing BUD31 function in pre-mRNA splicing.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphatidic Acid, Dioleoyl | 108392-02-5 | sc-201059 | 10 mg | $250.00 | 1 | |
Phosphatidic Acid is a key intermediate in the biosynthesis of lipids and acts as a signaling lipid. It can activate mitogen-activated protein kinase (MAPK), which in turn can enhance BUD31 activity by phosphorylation as BUD31 is involved in the splicing of pre-mRNA, a process regulated by phosphorylation events. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that activates signal transduction pathways involved in cell survival and proliferation. It can lead to the activation of kinases that may phosphorylate serine/arginine-rich (SR) proteins, which are known to interact with BUD31 in mRNA processing. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration and can enhance BUD31 activity by promoting the interaction between BUD31 and other calcium-binding splicing factors within the spliceosome. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate proteins involved in the regulation of splicing, potentially leading to enhanced BUD31 activity in pre-mRNA processing. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a PKC activator, and by activating PKC, it can phosphorylate substrates involved in RNA processing, potentially enhancing BUD31 function in mRNA splicing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit phosphodiesterases, leading to increased cAMP and cGMP levels, which in turn activates PKA and PKG. These kinases can phosphorylate splicing factors and potentially enhance BUD31 function in pre-mRNA splicing. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of various proteins. This can enhance BUD31 activity by preventing the dephosphorylation of splicing factors that interact with BUD31. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to increased cytosolic calcium levels. This can indirectly enhance BUD31 activity by promoting the phosphorylation of splicing factors within the spliceosome. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is another inhibitor of protein phosphatases 1 and 2A, similar to Okadaic Acid. It can maintain the phosphorylation state of splicing factors and enhance BUD31's role in the spliceosome assembly and mRNA processing. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates PKC, leading to the phosphorylation of SR proteins. Enhanced phosphorylation of these proteins can positively affect BUD31's involvement in spliceosome assembly and function. | ||||||