BRE Activators
BRE Activators are a distinct category of biochemical compounds that amplify the activity of the Brain and Reproductive Organ Expressed (BRE) protein through various molecular mechanisms. These activators work by engaging with specific signaling pathways that BRE is known to participate in, thereby enhancing its native functions within cellular processes. For example, certain BRE Activators might target the ubiquitin-proteasome system, a pathway with which BRE is intricately involved. By modulating the ubiquitination process, these activators can affect the degradation rate of proteins and thus indirectly increase the availability and stability of the BRE protein. This can lead to an upsurge in BRE's functional presence, facilitating its role in DNA damage repair and apoptosis. Other activators may interact with the BRE protein's involvement in intracellular trafficking. Through this interaction, they can influence the subcellular localization of BRE, ensuring that it is present in the right place at the right time to execute its cellular duties effectively, especially in the context of cell cycle control and signal transduction.
Furthermore, BRE Activators can enhance BRE's interaction with other proteins, such as those involved in cell adhesion and migration, by modulating the expression of surface receptors or the availability of binding partners. This enhancement can lead to improved cellular responses to environmental cues and a more accurate execution of BRE's roles in these critical processes. Additionally, some BRE Activators may work by influencing cellular energy pathways, like those involving ATP production, which BRE might tap into during cell stress or metabolic regulation. By ensuring an ample supply of energy, these activators can potentiate BRE's activities related to the maintenance of cellular homeostasis. These activators are invaluable tools for dissecting the biological functions of BRE, providing a deeper understanding of its role in cellular physiology. By manipulating the activity of BRE, scientists can observe changes in cell behavior and gain insights into how BRE contributes to maintaining the proper functioning of both brain and reproductive tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cyclic AMP (cAMP) levels, which activates protein kinase A (PKA). PKA can then phosphorylate specific substrates that may interact with BRE, thereby enhancing BRE's functional activity in cellular processes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) prevents the degradation of cAMP by inhibiting phosphodiesterases, which increases cAMP levels and indirectly enhances BRE activity through PKA activation and subsequent phosphorylation events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which may have downstream effects on BRE by altering phosphorylation patterns of proteins that interact with or regulate BRE. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, potentially affecting calcium-dependent protein kinases and phosphatases that could modify the activity or interaction partners of BRE. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, which may lead to an increase in the phosphorylation state of proteins that interact with BRE, indirectly enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is another inhibitor of protein phosphatases, which could similarly increase phosphorylation within BRE's signaling pathways, indirectly enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate sphingosine-1-phosphate receptors, which may engage signaling cascades that influence BRE function indirectly through alterations in cellular context and microenvironment. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases, potentially altering signaling pathways that indirectly enhance the functional activity of BRE by alleviating inhibitory controls or competitive signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that, by inhibiting PI3K, can alter downstream AKT signaling, which could indirectly modulate the functional activity of BRE through changes in cell survival and metabolism signals. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Similar to U0126, PD 98059 is a MEK inhibitor that affects the MAPK/ERK pathway, potentially leading to enhanced BRE activity through indirect effects on proteins that regulate or interact with BRE. | ||||||