BRE inhibitors constitute a class of chemical compounds that have garnered attention in the field of molecular biology and gene expression research. These inhibitors are specifically designed to target and modulate the activity of BRE, which stands for Brain and Reproductive Organ-Expressed protein. BRE is a relatively newly discovered protein that has been implicated in various cellular processes, including transcriptional regulation and cellular stress responses. While the exact functions of BRE are still under investigation, it is known to interact with key transcriptional regulators, such as RNA polymerase II and transcription factor IIB (TFIIB), suggesting a role in the regulation of gene expression.
BRE inhibitors exert their effects by interfering with the function or expression of BRE, disrupting its role in transcriptional control and stress responses. This interference can lead to alterations in gene expression patterns and cellular responses to various stressors, influencing cellular physiology and homeostasis. Researchers employ BRE inhibitors as valuable tools to investigate the specific roles of BRE in different cellular contexts and to gain insights into the molecular mechanisms governing gene expression and stress responses. While the precise applications and broader implications of BRE inhibitors are subjects of ongoing research, their utility in elucidating the intricacies of transcriptional regulation and cellular stress responses is of paramount importance in advancing our understanding of molecular and cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
A histone deacetylase inhibitor, potentially altering chromatin structure and affecting gene expression, including BRE. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
An antimetabolite that interferes with DNA synthesis, which could indirectly downregulate BRE expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, leading to DNA damage and potential alterations in DNA repair gene expression like BRE. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Targets DNA topoisomerase II, disrupting DNA repair mechanisms which could affect BRE levels indirectly. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
A PARP inhibitor, potentially altering DNA repair pathways and indirectly affecting BRE expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound with various cellular targets that may modulate transcription factor activity, potentially influencing BRE expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
A cyclin-dependent kinase inhibitor that can affect cell cycle progression and gene expression, including BRE. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
An isothiocyanate that activates Nrf2, potentially influencing the expression of DNA repair genes like BRE. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that may impact signal transduction and gene regulation, potentially altering BRE expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An aldehyde dehydrogenase inhibitor that can modulate various cellular pathways, potentially influencing BRE levels. | ||||||