BPIL2 Activators
BPI fold containing family C refers to a group of proteins that are part of the larger BPI (Bactericidal/Permeability-Increasing) fold-containing protein family. These proteins are characterized by having a BPI domain, which is known for its role in lipid binding and is typically involved in immune defense mechanisms, particularly in the recognition and neutralization of Gram-negative bacteria.
Proteins in the BPI fold containing family C possess a structurally conserved fold that is similar to that found in BPI, which is a potent antimicrobial protein. This fold is crucial for interaction with the lipid A portion of lipopolysaccharides (LPS) present on the outer membrane of Gram-negative bacteria. Through this interaction, members of the BPI family can exert bactericidal activity by disrupting the bacterial membrane or by opsonizing bacteria for enhanced clearance by immune cells.The BPI fold containing family C proteins may have evolved to perform specialized functions within the immune system. They could be involved in innate immune responses, participating in the initial defense against bacterial infections. Their exact roles may include binding to bacterial membranes, neutralizing endotoxins, or modulating immune cell activity. These proteins may also have a role in signaling, contributing to the inflammatory response by interacting with receptors on immune cells, thus influencing cytokine production and immune cell recruitment.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polymyxin B Sulfate | 1405-20-5 | sc-3544 | 500 mg | $63.00 | 8 | |
Polymyxin B binds to LPS and might indirectly affect the activity of these proteins by competing for LPS binding. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
TLR4 agonists might indirectly modulate the activity of BPI family proteins involved in TLR4 signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Corticosteroids, through their anti-inflammatory effects, might indirectly impact the role of BPI fold proteins in immune responses. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-kappa B inhibitors could indirectly influence these proteins by modulating inflammatory signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MAPK inhibitors might affect BPI fold containing family C proteins by altering signaling pathways involved inimmune responses. | | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Immunomodulators can influence the immune system broadly, potentially affecting the function of BPI fold proteins. | | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Non-steroidal anti-inflammatory drugs (NSAIDs) could indirectly affect the inflammatory context in which BPI fold proteins operate. | ||||||