Molecular structure of Polymyxin B Sulfate, CAS Number: 1405-20-5
Polymyxin B Sulfate (CAS 1405-20-5)
See product citations (8)
Application:
Polymyxin B Sulfate is an antibiotic mixture active against Gram (−) organisms
CAS Number:
1405-20-5
Molecular Weight:
1301.6
Molecular Formula:
C55H96N16O13•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Polymyxin B Sulfate also known as Aerosporin is a synthetic antibiotic developed in the late 1940s, encompassing a combination of two antibiotics, ampicillin and sulbactam. It has been widely utilized in scientific research for in vitro applications. In vitro, it has been employed to investigate the effects of antibiotics on bacterial cultures and human cells.Polymyxin B Sulfate exhibits broad-spectrum activity against a diverse range of bacteria, including both Gram-positive and Gram-negative strains.The mode of action of Polymyxin B Sulfate involves hindering bacterial growth through multiple mechanisms. It interferes with the synthesis of bacterial cell walls, impeding their formation and hindering bacterial replication. Additionally, Polymyxin B Sulfate disrupts the synthesis of bacterial DNA, thwarting bacterial reproduction.
Polymyxin B Sulfate (CAS 1405-20-5) References
- In vitro evaluation of nebulization properties, antimicrobial activity, and regional airway surface liquid concentration of liposomal polymyxin B sulfate. | Desai, TR., et al. 2003. Pharm Res. 20: 442-7. PMID: 12669966
- Pharmacodynamics of polymyxin B against Pseudomonas aeruginosa. | Tam, VH., et al. 2005. Antimicrob Agents Chemother. 49: 3624-30. PMID: 16127031
- Simultaneous determination of neomycin sulfate and polymyxin B sulfate by capillary electrophoresis with indirect UV detection. | Srisom, P., et al. 2007. J Pharm Biomed Anal. 43: 1013-8. PMID: 17116385
- Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats. | Shi, C., et al. 2007. Vascul Pharmacol. 46: 406-11. PMID: 17347056
- Antagonism of endotoxic glucose dyshomeostasis by protein kinase C inhibitors. | Inaba, H. and Filkins, JP. 1991. Am J Physiol. 261: R26-31. PMID: 1858953
- Polymyxin B is a selective and potent antagonist of calmodulin. | Hegemann, L., et al. 1991. Eur J Pharmacol. 207: 17-22. PMID: 1915592
- Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 degrees C. | He, J., et al. 2010. Am J Health Syst Pharm. 67: 1191-4. PMID: 20592326
- Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice. | Bannatyne, RM. and Cheung, R. 1979. Can J Microbiol. 25: 995-8. PMID: 232006
- Direct determination of polymyxin B sulfate using resonance Rayleigh scattering and resonance non-linear scattering methods with hexatungstate. | Kong, L., et al. 2014. Luminescence. 29: 29-35. PMID: 23299991
- Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept. | Li, X., et al. 2016. Pharmazie. 71: 327-33. PMID: 27455551
- Antimicrobial gelatin-based elastomer nanocomposite membrane loaded with ciprofloxacin and polymyxin B sulfate in halloysite nanotubes for wound dressing. | Shi, R., et al. 2018. Mater Sci Eng C Mater Biol Appl. 87: 128-138. PMID: 29549942
- Effects of agars on determination of potency of polymyxin B sulfate by the agar plate diffusion method. | Fujihara, M., et al. 1994. Antimicrob Agents Chemother. 38: 2665-7. PMID: 7872766
- In vitro interactions of neomycin sulfate, bacitracin, and polymyxin B sulfate. | Booth, JH., et al. 1994. Int J Dermatol. 33: 517-20. PMID: 7928043
- Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. | Soroff, HS. and Sasvary, DH. 1994. J Burn Care Rehabil. 15: 13-7. PMID: 8150836
- Inhibition of lipopolysaccharide-induced macrophage tumor necrosis factor-alpha synthesis by polymyxin B sulfate. | Coyne, CP. and Fenwick, BW. 1993. Am J Vet Res. 54: 305-14. PMID: 8430940
Inhibitor of:
α-defensin 4, β-defensin 126, Bacteroides LPS, C. abortus LPS, C. trachomatis MOMP, CRS1C-3, CRS4C-2, cryptdin 24, cryptdin 25, cryptdin 26, cryptdin 4, Edwardsiella tarda, Francisella tularensis LPS, GRAMD2, HNP-1, LBP, Legionella pneumophila LPS, LL-37, LPLUNC1, PKC, Salmonella (Enterobacterales), Salmonella flagella, Salmonella LPS, Salmonella paratyphi 0-2, Ser/Thr Protein Kinase, and Shigatoxin 2.Activator of:
β-defensin 108B, β-defensin 3B, Aspergillus, BPIL2, Brucella abortus LPS, CD206, CD209g, Dcp1, Dpl, Gram Negative Endotoxin Marker, LBP1, Lipid A, and Siglec-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Polymyxin B Sulfate, 500 mg | sc-3544 | 500 mg | $62.00 |