BMP-8A Activators
BMP-8A Activators are a specialized class of chemical compounds that play a pivotal role in enhancing the biological activity of the protein BMP-8A. BMP-8A, short for Bone Morphogenetic Protein 8A, is a member of the TGF-beta superfamily and is intricately involved in a range of developmental processes, including but not limited to embryogenesis and bone formation. Activators of BMP-8A are highly specific molecules that facilitate the protein's function by augmenting its signaling pathway. These compounds typically engage by directly binding to BMP-8A or its receptors, thereby promoting the protein's interaction with its serine/threonine kinase receptors. This interaction leads to the phosphorylation of SMAD proteins, which are critical transducers in BMP signaling. Once phosphorylated, SMAD proteins translocate to the nucleus and modulate the expression of genes that are downstream targets of BMP-8A signaling. The specificity of BMP-8A Activators lies in their ability to preferentially enhance the signaling cascade of BMP-8A without broadly affecting the myriad of other proteins within the TGF-beta superfamily.
The biochemical mechanisms by which BMP-8A Activators function are a testament to the complexity and precision of cellular signaling pathways. Some activators work by stabilizing the BMP-8A ligand-receptor complex, increasing the protein's half-life and its signaling efficacy. Others might mimic the structure of BMP-8A's natural ligands, competitively binding to receptors with higher affinity and thus amplifying the natural signaling events. There are also activators that influence the localization and availability of co-receptors or auxiliary molecules necessary for BMP-8A-mediated signaling, ensuring that the signaling complex is assembled more efficiently. These activators can also modulate the activity of proteinases that activate BMP-8A by cleavage, ensuring an optimal level of active protein is available for signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate Smad1/5/8 proteins, enhancing the BMP-8A signaling pathway and its functional activity in bone formation and repair. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin inhibits BMP type I receptors ALK2, ALK3, and ALK6, which paradoxically can enhance BMP-8A function through a feedback mechanism that compensates for the inhibited receptors, thus leading to upregulation of BMP-8A signaling in chondrogenesis. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 is a selective inhibitor of BMP type I receptors ALK2 and ALK3. Similar to Dorsomorphin, it can induce a compensatory increase in BMP-8A signaling through feedback mechanisms in embryonic stem cell differentiation. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
Parathyroid hormone fragment (1-34), known as Teriparatide, increases bone formation by enhancing the cAMP-PKA pathway, which can indirectly stimulate BMP-8A signaling involved in osteogenesis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which leads to stabilization and accumulation of β-catenin. β-Catenin can enhance BMP-8A signaling by cooperative interaction with Smads in osteoblast differentiation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor ALK5, which can upregulate BMP signaling by reducing the competition for Smad proteins, indirectly enhancing BMP-8A activity in mesenchymal stem cell differentiation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol enhances the body's absorption of calcium and phosphate, which are necessary for BMP-8A mediated bone mineralization and growth. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates the differentiation of various cells. It can potentiate BMP-8A signaling by upregulating its receptors or downstream effectors involved in developmental processes. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
L-Ascorbic acid is essential for collagen synthesis and osteoblast differentiation, where it can enhance BMP-8A signaling pathways that are crucial for bone formation. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium is necessary for the structural integrity of bones and the activity of enzymes that facilitate BMP-8A signaling in bone development and repair. | ||||||