Date published: 2025-9-6

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BMP-4 Activators

Common BMP-4 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, Forskolin CAS 66575-29-9, 5-Aza-2′-Deoxycytidine CAS 2353-33-5 and Lithium Chloride CAS 7447-41-8.

Bone Morphogenetic Protein 4 (BMP-4) is a member of the transforming growth factor-beta (TGF-β) superfamily, a group of proteins known for their influential roles in cellular processes and developmental biology. BMP-4, in particular, holds a significant place in embryogenesis, tissue development, and organogenesis. Its activity is evident in a variety of developmental events, ranging from the establishment of body axes during embryonic development to the differentiation of various cell types in diverse tissues. By binding to its specific receptors on cell surfaces, BMP-4 triggers a cascade of intracellular signaling events that culminate in the transcriptional regulation of target genes. The tightly regulated expression and activity of BMP-4 ensure that developmental processes occur in a timely and orderly manner, orchestrating the intricate symphony of events that give rise to functional tissues and organs.

Activators of BMP-4 are molecules or compounds that enhance the expression or activity of BMP-4. These activators might function by promoting BMP-4 synthesis, stabilizing its structure, or enhancing its interaction with cellular receptors. They could also amplify the downstream signaling pathways triggered by BMP-4, leading to a heightened cellular response. The presence of BMP-4 activators can influence various developmental processes, amplifying or refining the cellular outcomes governed by this protein. Exploring the realm of BMP-4 activators offers a deep dive into the world of developmental signaling and the molecular cues that shape organisms. As research continues to unveil the mysteries of development and tissue formation, the role of BMP-4 and its activators emerges as a central theme, highlighting the intricate molecular narratives that craft the tapestry of life.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid can influence BMP-4 expression during differentiation and embryonic development.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

In osteoblastic differentiation, dexamethasone can enhance BMP-4 expression.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Increases intracellular cAMP levels, potentially leading to upregulation of BMP-4 expression.

Bisphenol A

80-05-7sc-391751
sc-391751A
100 mg
10 g
$300.00
$490.00
5
(0)

In certain contexts, BPA exposure has been reported to increase BMP-4 expression.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

DNA methylation inhibitor that can reactivate the expression of silenced genes, potentially influencing BMP-4 expression.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

LiCl inhibits GSK-3β and can induce BMP-4 expression in specific contexts.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA can modulate various cellular pathways, potentially influencing BMP-4 expression in some contexts.

Puerarin

3681-99-0sc-202301
sc-202301A
5 mg
100 mg
$129.00
$205.00
1
(0)

Puerarin, an isoflavone, has been reported to enhance BMP-4 expression in osteoblast differentiation.