Bone Morphogenetic Protein 4 (BMP-4) is a member of the transforming growth factor-beta (TGF-β) superfamily, a group of proteins known for their influential roles in cellular processes and developmental biology. BMP-4, in particular, holds a significant place in embryogenesis, tissue development, and organogenesis. Its activity is evident in a variety of developmental events, ranging from the establishment of body axes during embryonic development to the differentiation of various cell types in diverse tissues. By binding to its specific receptors on cell surfaces, BMP-4 triggers a cascade of intracellular signaling events that culminate in the transcriptional regulation of target genes. The tightly regulated expression and activity of BMP-4 ensure that developmental processes occur in a timely and orderly manner, orchestrating the intricate symphony of events that give rise to functional tissues and organs.
Activators of BMP-4 are molecules or compounds that enhance the expression or activity of BMP-4. These activators might function by promoting BMP-4 synthesis, stabilizing its structure, or enhancing its interaction with cellular receptors. They could also amplify the downstream signaling pathways triggered by BMP-4, leading to a heightened cellular response. The presence of BMP-4 activators can influence various developmental processes, amplifying or refining the cellular outcomes governed by this protein. Exploring the realm of BMP-4 activators offers a deep dive into the world of developmental signaling and the molecular cues that shape organisms. As research continues to unveil the mysteries of development and tissue formation, the role of BMP-4 and its activators emerges as a central theme, highlighting the intricate molecular narratives that craft the tapestry of life.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence BMP-4 expression during differentiation and embryonic development. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
In osteoblastic differentiation, dexamethasone can enhance BMP-4 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases intracellular cAMP levels, potentially leading to upregulation of BMP-4 expression. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
In certain contexts, BPA exposure has been reported to increase BMP-4 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
DNA methylation inhibitor that can reactivate the expression of silenced genes, potentially influencing BMP-4 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3β and can induce BMP-4 expression in specific contexts. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can modulate various cellular pathways, potentially influencing BMP-4 expression in some contexts. | ||||||
Puerarin | 3681-99-0 | sc-202301 sc-202301A | 5 mg 100 mg | $129.00 $205.00 | 1 | |
Puerarin, an isoflavone, has been reported to enhance BMP-4 expression in osteoblast differentiation. |