BLM Activators
The BLM RecQ-like helicase activators belong to a specialized class of molecules that play a pivotal role in the modulation of the activity of BLM helicases, which are enzymes that unwind DNA. Helicases are crucial for numerous cellular processes including DNA replication, repair, and recombination. Specifically, the BLM helicase, named after the Bloom syndrome it's associated with, is a member of the RecQ family of helicases. In humans, mutations in this helicase can lead to a predisposition to a wide variety of cancers and other genomic instabilities. This is due to the critical function of the BLM helicase in maintaining genomic integrity by resolving complex DNA structures that arise during DNA replication and repair.
Helicase activators are molecules that enhance the efficiency of helicases in their function. In the context of the BLM RecQ-like helicase, these activators play a role in facilitating the unwinding process by assisting the helicase in its interaction with DNA, potentially helping it navigate and process complex DNA structures. The intricate interplay between BLM helicase and its activators is crucial for ensuring the proper functioning of the DNA metabolic processes in which the helicase is involved. Any disruptions or aberrations in this relationship can result in genomic instability, which underscores the significance of these activators in cellular biology. Research into the precise molecular mechanisms of these activators and their interaction with BLM helicases is ongoing, as understanding these processes can shed light on fundamental cellular mechanisms related to DNA maintenance and stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound from turmeric, has been shown to influence various pathways related to DNA damage and repair. Its potential in inducing BLM expression may be linked to its role in modulating cellular response to genotoxic stress. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in red grapes, has been connected to the regulation of various genes involved in DNA repair. It might influence BLM expression by modulating pathways that sense DNA damage. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone in soybeans, has demonstrated roles in affecting DNA repair mechanisms. Its potential to induce BLM expression may relate to its influence on DNA damage responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, from cruciferous vegetables, has shown potential in modulating cellular stress pathways. It might affect BLM expression due to its role in responding to oxidative DNA damage. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been linked to influencing DNA repair mechanisms. Its ability to possibly induce BLM might be due to its effect on genomic stability pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, from green tea, has shown antioxidant properties and potential in modulating DNA repair genes. Its influence on BLM expression might be linked to its role in mitigating DNA damage. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid, a phenolic acid, has been associated with influencing cellular pathways related to DNA damage and repair. It may induce BLM expression by modulating these pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine has demonstrated potential effects on various cellular mechanisms including DNA repair. Its potential induction of BLM may be linked to its action on DNA damage response pathways. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, found in berries, has antioxidant properties and has been connected to DNA repair pathways. Its potential role in inducing BLM might be due to its effect on genomic stability mechanisms. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin, a flavonoid, has been researched for its potential effects on DNA damage responses. It might influence BLM expression through its action on DNA repair pathways. | ||||||