β2-crystallin Activators
Chemical activators of β2-crystallin include a variety of compounds that can contribute to the stability and proper function of the protein. Zinc sulfate, for instance, can bind to the quaternary structure of β2-crystallin. This binding can help stabilize the overall structure of the protein, maintaining its solubility and functional activity, which is vital for the clarity of the ocular lens. Similarly, sodium selenite provides selenium, an essential micronutrient that supports the antioxidant defense system in ocular tissues. This support can maintain the conformation and function of β2-crystallin, especially under conditions of oxidative stress. Ascorbic acid, another antioxidant, can engage in the reduction of oxidative stress within the eye, assisting in preserving the active conformation of β2-crystallin.
Furthermore, alpha-lipoic acid can protect β2-crystallin from oxidative damage, maintaining its structural integrity. The preservation of this integrity is crucial for the continued functional activity of β2-crystallin within the lens. Another compound, glutathione, serves as a major intracellular antioxidant and can contribute to the reduction of disulfide bonds that may form under oxidative stress. This reduction is essential for preventing the aggregation of β2-crystallin, which is important for its activity. Taurine can aid in osmoregulation and the stabilization of cellular membranes, indirectly benefiting β2-crystallin's functional status by maintaining the cellular environment. N-Acetylcysteine can bolster intracellular glutathione levels and directly scavenge free radicals, offering protection to β2-crystallin from oxidative modifications. Vitamin E, a lipid-soluble antioxidant, can protect the lipid membranes of lens cells, indirectly supporting the proper folding and function of β2-crystallin. Other compounds like curcumin, with its anti-inflammatory and antioxidant properties, can maintain the solubility and prevent the aggregation of β2-crystallin. Similarly, resveratrol, through the activation of the SIRT1 pathway, can foster a cellular environment that resists oxidative stress, aiding in the maintenance of β2-crystallin activity. Lastly, carotenoids such as lutein and zeaxanthin can protect ocular tissues from oxidative stress and light-induced damage, thereby assisting in the stabilization and activity of β2-crystallin.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can stabilize the structure of β2-crystallin by binding to its quaternary structure, which can lead to an increase in its stability and solubility, thus enhancing its functional activity in the lens of the eye. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Selenium, provided through sodium selenite, is an essential micronutrient that can contribute to the antioxidant defense system in ocular tissues, potentially preserving the function and conformation of β2-crystallin under oxidative stress conditions. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is a known antioxidant that can reduce oxidative stress in ocular tissues. It may help maintain the active conformation of β2-crystallin and prevent its aggregation, thereby sustaining its activity in the lens. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid functions as an antioxidant that can help to protect β2-crystallin from oxidative damage, thus maintaining its structural integrity and functional activity in the lens. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione, as a major intracellular antioxidant, can contribute to the reduction of disulfide bonds formed under oxidative stress, which could otherwise lead to the aggregation of β2-crystallin, and thus maintains its functional activation. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
Taurine may support osmoregulation and stabilization of cell membranes, which can indirectly benefit the functional status of β2-crystallin by preserving the cellular environment in which it operates. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine can contribute to the replenishment of intracellular glutathione levels and directly scavenge free radicals, potentially protecting β2-crystallin from oxidative modifications that could impair its activity. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Vitamin E is a lipid-soluble antioxidant that can protect the lipid membranes of lens cells, indirectly supporting the proper folding and function of β2-crystallin by preserving the overall cellular health. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin possesses anti-inflammatory and antioxidant properties. It can help maintain the solubility and prevent the aggregation of β2-crystallin by minimizing oxidative stress within the lens. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is an antioxidant that can activate the SIRT1 pathway, which has been implicated in cellular stress resistance. It may contribute to the maintenance of β2-crystallin activity by fostering a cellular environment that resists oxidative stress. | ||||||