β2-Adaptin Inhibitors
β2-Adaptin Inhibitors are compounds that, while not directly inhibiting β2-Adaptin, might influence its activity indirectly. These compounds primarily affect cellular phosphorylation status, thereby potentially influencing the function of β2-Adaptin as part of the AP-1 complex. For instance, H-89, Staurosporine, and Rottlerin all exhibit inhibitory effects on protein kinases, which can modulate the phosphorylation status of proteins. Thus, they can indirectly influence β2-Adaptin.
Conversely, Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, preventing protein dephosphorylation. While this can potentially activate β2-Adaptin by altering the phosphorylation status of proteins, it's important to note that maintaining a balance in phosphorylation is critical for cellular function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is an inhibitor of protein kinase A (PKA), which can modulate the phosphorylation status of proteins. By inhibiting PKA, H-89 could indirectly influence the function of β2-Adaptin. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, including PKC. By inhibiting PKC-mediated phosphorylation, it could indirectly influence β2-Adaptin. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $82.00 $163.00 $296.00 $2050.00 $5110.00 $16330.00 | 51 | |
Rottlerin is a selective inhibitor of PKCδ. By inhibiting this specific PKC isoform, Rottlerin could indirectly influence β2-Adaptin. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A. Despite being listed as an activator, it is important to note that excessive inhibition of dephosphorylation can disrupt the balance of phosphorylation, potentially affecting β2-Adaptin in a negative way. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Similar to Okadaic Acid, while it can prevent the dephosphorylation process and potentially activate β2-Adaptin, excessive inhibition can disrupt the balance and negatively affect β2-Adaptin. | ||||||