BC055107 Activators
Fam107a, a member of the family with sequence similarity 107, plays a crucial role in cellular processes, particularly in actin organization and regulation. Predicted to enable actin binding activity, Fam107a is involved in diverse processes such as actin filament organization, cellular response to glucocorticoid stimulus, and negative regulation of long-term synaptic potentiation. Its localization in the actin cytoskeleton, neuron projections, and synapses highlights its importance in structural and functional aspects of cellular physiology. Fam107a is expressed in critical regions such as the diencephalon ventricular layer, hypothalamus ventricular layer, inner ear, and olfactory epithelium, emphasizing its significance in neural and sensory tissues.
While direct activators of Fam107a may not be identified, several chemicals indirectly influence its activity through modulation of specific signaling pathways. Actin polymerization inhibitors like Latrunculin A and Cytochalasin D directly impact Fam107a by disrupting actin dynamics, altering cellular structures. Stabilizing actin filaments with Jasplakinolide promotes direct activation by enhancing Fam107a's binding activity. Indirectly, Rho kinase inhibitors like Y-27632 and myosin II inhibitors like Blebbistatin influence Fam107a through the modulation of the Rho/ROCK pathway and myosin-dependent contractility, respectively. Furthermore, formin inhibitors such as SMIFH2 and CK-548, as well as Arp2/3 complex inhibitors like CK-666, indirectly activate Fam107a by disrupting actin filament elongation and branching, respectively. Myosin light chain kinase inhibitors, including CK-689 and ML-7, provide indirect activation by influencing myosin II phosphorylation. Fam107a's intricate involvement in actin dynamics and its responsiveness to various chemical modulators highlight its significance in cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin polymerization inhibitor, directly influences Fam107a by disrupting actin dynamics. Inhibition of actin polymerization alters cellular structures, impacting Fam107a's binding activity. Latrunculin A’s role in actin organization provides a direct activation mechanism for Fam107a through its impact on the actin cytoskeleton and associated cellular processes. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide, an actin stabilizer, directly activates Fam107a by promoting actin filament stability. Stabilizing actin filaments enhances Fam107a's binding activity, impacting actin cytoskeleton organization. Jasplakinolide’s role in actin stabilization establishes a direct activation mechanism for Fam107a through its influence on actin dynamics and associated cellular processes. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666, an Arp2/3 complex inhibitor, indirectly activates Fam107a by disrupting actin filament branching. Inhibition of Arp2/3 complex influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. CK-666’s role in actin organization provides an indirect activation mechanism for Fam107a through its impact on actin filament branching and associated cellular processes. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D, an actin polymerization inhibitor, directly influences Fam107a by disrupting actin dynamics. Inhibition of actin polymerization alters cellular structures, impacting Fam107a's binding activity. Cytochalasin D’s role in actin organization provides a direct activation mechanism for Fam107a through its influence on the actin cytoskeleton and associated cellular processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a Rho kinase inhibitor, indirectly activates Fam107a by modulating the Rho/ROCK pathway. Inhibition of Rho kinase influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. Y-27632’s role in Rho/ROCK pathway regulation establishes an indirect activation mechanism for Fam107a through its impact on actin dynamics and associated cellular processes. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2, a formin inhibitor, indirectly activates Fam107a by disrupting actin filament elongation. Inhibition of formin influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. SMIFH2’s role in actin organization provides an indirect activation mechanism for Fam107a through its impact on actin filament elongation and associated cellular processes. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin, a myosin II inhibitor, indirectly activates Fam107a by modulating myosin-dependent contractility. Inhibition of myosin II influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. Blebbistatin’s role in myosin-dependent contractility regulation establishes an indirect activation mechanism for Fam107a through its impact on actin dynamics and associated cellular processes. | ||||||
CK-689 | 170930-46-8 | sc-507371 | 25 mg | $312.00 | ||
CK-689, a myosin light chain kinase (MLCK) inhibitor, indirectly activates Fam107a by disrupting myosin II phosphorylation. Inhibition of MLCK influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. CK-689’s role in MLCK inhibition provides an indirect activation mechanism for Fam107a through its impact on myosin II phosphorylation and associated cellular processes. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869, a myosin II inhibitor, indirectly activates Fam107a by modulating myosin-dependent contractility. Inhibition of myosin II influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. CK-869’s role in myosin-dependent contractility regulation establishes an indirect activation mechanism for Fam107a through its impact on actin dynamics and associated cellular processes. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7, a myosin light chain kinase (MLCK) inhibitor, indirectly activates Fam107a by disrupting myosin II phosphorylation. Inhibition of MLCK influences actin cytoskeleton dynamics, affecting Fam107a's binding activity. ML-7’s role in MLCK inhibition provides an indirect activation mechanism for Fam107a through its impact on myosin II phosphorylation and associated cellular processes. | ||||||