Basal bodies Activators
Basal Body Activators are a diverse class of chemical compounds that can influence the function and dynamics of basal bodies in eukaryotic cells. These activators exert their influence primarily by interacting with the microtubule and actin networks, which are integral to the structure and function of basal bodies.The compounds can be broadly categorized based on their target - microtubule or actin. Microtubule-targeting compounds include Forskolin, Paclitaxel, Nocodazole, Vinblastine, Colchicine, Taxol, Epothilone B, and Combretastatin. These compounds can modulate the dynamics of microtubules - stabilizing them or disrupting their dynamics.
The stability of the microtubule network is vital for the structural integrity and function of basal bodies, as these organelles originate from a mother centriole and are involved in ciliogenesis, where they form the base of the cilia.Compounds such as Cytochalasin D, Latrunculin A, Jasplakinolide, and Phalloidin target the actin network. Actin dynamics play a critical role in maintaining cellular structure, and changes in actin dynamics can influence the cellular processes related to basal bodies. These compounds act by either inhibiting actin polymerization or promoting it, thereby affecting the actin dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can activate adenylate cyclase, increasing cyclic AMP levels, which can influence microtubule polymerization, an essential process for basal body function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization, which can indirectly support the structural integrity of basal bodies. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, potentially influencing basal body activity by affecting microtubule organization. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule dynamics, which can indirectly influence the activities of basal bodies. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, potentially influencing cellular processes related to basal bodies. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers, affecting actin dynamics and potentially indirectly influencing basal body function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide promotes actin polymerization, potentially influencing cellular processes related to basal bodies. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds and stabilizes actin filaments, potentially influencing cellular processes related to basal bodies. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules, potentially supporting basal body functions by preserving microtubule structure. | ||||||