BAP31 Activators
BAP31, also known as B-cell receptor-associated protein 31, is an integral membrane protein primarily localized in the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment (ERGIC). Its multifunctional nature encompasses roles in protein trafficking, apoptosis regulation, and immune responses. One of BAP31's pivotal functions involves facilitating the transport of proteins between the ER and the Golgi apparatus. Acting as a cargo receptor, BAP31 aids in shuttling proteins from the ER to the Golgi for further processing and eventual secretion. Additionally, BAP31 serves as a crucial player in regulating ER stress responses and apoptotic pathways by acting as a scaffold for the assembly of signaling complexes. These complexes involve interactions with various proteins, including members of the Bcl-2 family and procaspase-8, thereby modulating apoptotic signaling cascades and influencing cell fate decisions such as survival or death, depending on cellular conditions.
The activation of BAP31 involves intricate regulatory mechanisms that govern its participation in cellular processes. One primary activation mechanism entails post-translational modifications, such as phosphorylation or glycosylation, which can modulate BAP31's activity and interaction with binding partners. Additionally, BAP31 activation may be regulated by its subcellular localization and trafficking dynamics between the ER and the Golgi. Stimuli such as cellular stress or specific signaling events may trigger changes in BAP31 localization, promoting its involvement in protein trafficking or apoptotic signaling pathways. Furthermore, the assembly of protein complexes involving BAP31, mediated by its interactions with other cellular proteins, can also contribute to its activation and subsequent functional outcomes. Overall, understanding the mechanisms of BAP31 activation provides valuable insights into its diverse roles in cellular physiology and its potential implications for various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) signaling. BAP31 is a substrate for PKC phosphorylation. PMA-induced PKC activation enhances BAP31 phosphorylation, leading to altered protein-protein interactions within the endoplasmic reticulum. This modification enhances BAP31's role in vesicular transport and ER stress responses. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces ER calcium depletion, activating calcium-dependent signaling pathways. BAP31 is implicated in calcium homeostasis within the endoplasmic reticulum. Thapsigargin-induced calcium depletion enhances BAP31 function by promoting its involvement in ER-associated degradation (ERAD) and altered protein trafficking, leading to enhanced cellular responses to unfolded proteins and ER stress. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased intracellular cAMP levels. BAP31 is associated with cAMP-dependent signaling pathways. Forskolin-induced elevation of cAMP enhances BAP31 function by influencing its interactions with other signaling molecules, leading to altered cellular responses to cyclic nucleotide signaling and impacting BAP31-mediated processes within the endoplasmic reticulum. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB modulates intracellular calcium levels. BAP31 is implicated in calcium homeostasis within the endoplasmic reticulum. 2-APB-induced alterations in calcium dynamics enhance BAP31 function by promoting its involvement in ER-associated degradation (ERAD) and altered protein trafficking, leading to enhanced cellular responses to unfolded proteins and ER stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG modulates the ERK/MAPK signaling pathway. BAP31 is associated with ERK/MAPK-mediated signaling events. EGCG-induced modulation of ERK/MAPK signaling enhances BAP31 function by influencing its interactions with signaling components, leading to altered cellular responses to growth factor signaling and impacting BAP31-mediated processes within the endoplasmic reticulum. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable analog of cyclic AMP (cAMP) that activates cAMP-dependent signaling pathways. BAP31 is associated with cAMP-mediated signaling events. 8-Bromo-cAMP-induced elevation of cAMP enhances BAP31 function by influencing its interactions with other signaling molecules, leading to altered cellular responses to cyclic nucleotide signaling and impacting BAP31-mediated processes within the endoplasmic reticulum. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A inhibits protein phosphatases, leading to increased phosphorylation events. BAP31 is a substrate for various kinases. Calyculin A-induced protein phosphorylation enhances BAP31 function by promoting its interactions with other signaling molecules, leading to altered cellular responses to kinase signaling and impacting BAP31-mediated processes within the endoplasmic reticulum. | ||||||