Atase Inhibitors
Chemical inhibitors of Atase target the purine synthesis pathway to achieve functional inhibition. Methotrexate, a dihydrofolate reductase inhibitor, indirectly inhibits Atase by limiting the production of purine nucleotides, which are essential substrates for Atase's enzymatic function. Mycophenolic acid and Ribavirin, both inosine monophosphate dehydrogenase inhibitors, further reduce the guanosine nucleotide pool, thereby constraining Atase's substrate availability. Purine analogs such as 6-Mercaptopurine and 6-Thioguanine compete with natural substrates for the active site of Atase, thereby preventing the enzyme from performing its role in nucleotide biosynthesis. Azathioprine, metabolized into 6-Mercaptopurine, employs a similar strategy to impede Atase by competing with purine substrates.
Clofarabine and Fludarabine, nucleotide analogs, are known to inhibit enzymes in nucleotide metabolism, resulting in a reduced pool of nucleotides, which indirectly limits Atase's functionality due to a lack of substrates. Cladribine, another purine analog, interferes with nucleic acid metabolism, leading to a decreased nucleotide pool that indirectly restricts Atase's action. Tiazofurin reduces purine synthesis by inhibiting inosine monophosphate dehydrogenase, which in turn limits the substrates required for Atase activity. Acyclovir, primarily recognized for its antiviral properties, is a guanine analog that competes with guanine nucleotides, and its incorporation can inadvertently diminish the pool of substrates needed by Atase. Didanosine, an adenosine analog, upon phosphorylation and incorporation into DNA, can disrupt DNA synthesis, indirectly leading to a reduced demand for the nucleotides synthesized by Atase, thus hindering the enzyme's function within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that can indirectly inhibit Atase by reducing the availability of purine nucleotides, which are necessary substrates for Atase's enzymatic activity in nucleotide biosynthesis. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to a depletion of guanosine nucleotides. This reduction in guanosine nucleotides can functionally inhibit Atase by limiting the pool of substrates required for its activity in purine synthesis. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
6-Mercaptopurine is a purine analog that inhibits several enzymes involved in purine synthesis. By incorporating into nucleotide pathways, it can indirectly inhibit Atase by competing with the natural substrates for the enzyme's active site. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
6-Thioguanine acts similarly to 6-Mercaptopurine, by being a purine analog. It competes with purine nucleotides and can indirectly inhibit Atase by interfering with its natural substrate's binding and subsequent enzymatic action. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine is a pro-drug that is converted into 6-Mercaptopurine in the body. It can indirectly inhibit Atase by acting through its metabolite, which competes with the natural purine substrates for Atase activity. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin is a nucleoside analog that inhibits inosine monophosphate dehydrogenase. By reducing guanosine nucleotide synthesis, it indirectly inhibits Atase by decreasing the substrate pool necessary for its function in purine nucleotide biosynthesis. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
Clofarabine is a purine nucleoside analog that can inhibit ribonucleotide reductase and other enzymes involved in nucleotide metabolism. Its action can lead to a reduction in nucleotide pools, indirectly inhibiting Atase by substrate limitation. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine, a nucleotide analog, can be incorporated into DNA and interfere with DNA synthesis. This can indirectly inhibit Atase through feedback inhibition, as the disruption of DNA synthesis can lead to a decreased demand for the nucleotides that Atase helps synthesize. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
Cladribine is a purine analog that disrupts nucleic acid metabolism and can cause a depletion of the nucleotide pool. This depletion indirectly inhibits Atase by reducing the availability of its substrates. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $440.00 | ||
Tiazofurin is an inhibitor of inosine monophosphate dehydrogenase, which can lead to lowered purine synthesis. This reduction can functionally inhibit Atase by decreasing the availability of purine ribonucleotides necessary for its activity. | ||||||