Atase Activators
Atase Activators constitute a diverse group of compounds primarily centered around the modulation of intracellular cAMP levels. As Atase function is intricately linked with the cAMP-dependent PKA signaling pathway, compounds that elevate cAMP levels generally serve to enhance Atase activity. Phosphodiesterase inhibitors like Rolipram, Dipyridamole, IBMX, Cilostamide, Milrinone, Anagrelide, Zaprinast, Sildenafil, and Theophylline act by preventing the degradation of cAMP, effectively sustaining an elevated intracellular concentration of this cyclic nucleotide. This sustained cAMP presence ensures continuous activation of PKA, which in turn can phosphorylate multiple downstream targets, thereby potentiating the Atase-mediated signaling cascade. These activators, despite their varied specificity for different phosphodiesterase isoforms, converge on the common outcome of bolstering Atase activity.
On the other hand, compounds like Adenosine and Forskolin directly influence the production of cAMP. Adenosine, through its interaction with adenosine receptors, and Forskolin, by directly activating adenylyl cyclase, both lead to an increased synthesis of cAMP. The resultant accumulation of cAMP within the cell ensures the active engagement of PKA, which is a pivotal kinase for Atase function. Through the phosphorylation of specific substrates, PKA catalyzes reactions that underpin the physiological roles attributed to Atase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with cell surface receptors, which initiates a signaling cascade that increases intracellular cAMP levels, thereby enhancing Atase activity as cAMP facilitates the protein's interactions with its targets. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP, which in turn activates PKA and promotes Atase-associated signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, leading to elevated cAMP levels, which can indirectly increase Atase activity through PKA activation. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole inhibits phosphodiesterase, leading to increased cAMP levels and subsequent enhancement of Atase activity through PKA activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that elevates cAMP levels, thereby potentially enhancing Atase activity via PKA signaling. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Cilostamide selectively inhibits phosphodiesterase-3, raising cAMP levels, which could indirectly lead to increased Atase activity through PKA. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone is a phosphodiesterase-3 inhibitor that increases cAMP concentration, indirectly enhancing Atase function via PKA-dependent pathways. | ||||||
Anagrelide hydrochloride | 58579-51-4 | sc-203513 sc-203513A | 10 mg 50 mg | $103.00 $587.00 | 1 | |
By inhibiting phosphodiesterase-3, anagrelide increases cAMP levels, potentially enhancing Atase activity through PKA-mediated signaling. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase-5, increasing cAMP levels and possibly enhancing Atase activity through downstream PKA signaling. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline, a non-selective phosphodiesterase inhibitor, raises cAMP levels, leading to enhanced Atase activity through PKA activation. | ||||||