Rolipram (CAS 61413-54-5)

5.0(1)

리부쓰기 문의하기

인용논문 보기 (17)

Alternate Names: SB 95952; ZK 62711

Application Rolipram is a selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4)

CAS 등록번호: 61413-54-5

순도: ≥97%

분자량: 275.35

분자식: C₁₆H₂₁NO₃

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

* 참조분석증명서대량의 측정 데이터(함수량포함).

빠른 링크

이미지나 확대버튼을 클릭하면 확대이미지를 열람할수있습니다.

Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC₅₀=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.

References

1. Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127: 105-115. PMID: 3019721
2. Reeves, M.L., et al. 1987. Biochem. J. 241: 535-541. PMID: 3036066
3. Moore, J.B., et al. 1991. Biochem. Pharmacol. 42: 679-683. PMID: 1650219
4. Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270: 250-259. PMID: 8035322
5. Zhu, W.H., et al. 1998. Life Sci. 63: 265-274. PMID: 9698035
6. Bivalacqua, T.J., et al. 1999. J. Urol. 162: 1848-1855. PMID: 10524946
7. Sasaki, T., et al. 2007. Stroke. 38: 1597-1605. PMID: 17379823
8. Kaneda, T., et al. 2010. J Smooth Muscle Res. 46: 17-29. PMID: 20383031

사용법 :

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

Physical State :

Solid

용해도 :

Soluble in water (0.2 mg/mL ), DMSO (7.3 mg/ml ), ethanol (7 mg/ml warm), DMF (~10 mg/ml ), DMF:PBS (pH 7.2, 1:9) (~0.5 mg/ml ), and acetone (25 mg/ml).

저장 :

Store at 4° C

녹는점 :

184.12° C (Predicted)

비등점 :

~472.7° C at 760 mmHg (Predicted)

밀도 :

~1.2 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.55

IC50 :

cAMP-specific phosphodiesterase (PDE4): IC₅₀ = 1 µM; C5a-stimulated LTC4 synthesis: IC₅₀ = 200 nM (eosinophils); lipopolysaccharide-induced TNF synthesis: IC₅₀ = 360 nM (monocytes); Phosphodiesterase 4A: IC₅₀ = 4 nM (mouse); Phosphodiesterase 4B: IC₅₀ = 34 nM (human); Phosphodiesterase 4D: IC₅₀ = 25 nM (human); Phosphodiesterase 4C: IC₅₀ = 25 nM (human)

Ki 데이타 :

Phosphodiesterase 4A: K_i= 0.0023 nM (Rattus norvegicus); Phosphodiesterase 4D: K_i= 1.6 nM (human); Phosphodiesterase 4B: K_i= 3.8 nM (human); Phosphodiesterase 4C: K_i= 0.0023 nM (Rattus norvegicus)

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

WGK Germany :

RTECS :

UY5749237

PubChem CID :

5092

Merck Index :

14: 8251

MDL Number :

MFCD00270906

EC Number :

262-771-1

SMILES :

COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

SDS(MSDS)다운로드

Region

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Rolipram (CAS 61413-54-5) 논문정보

다른 사용자의 Rolipram (CAS 61413-54-5)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 10 of 17 합계

PMID: # 26416856 Euba, B. et al. 2015. Antimicrob. Agents Chemother. 59: 7581-92.

PMID: # 18372231 Levallet, G. et al. 2008. J. Endocrinol. 197: 45-54.

PMID: # 18641359 Hervé, R et al. 2008. J. Immunology. 181: 2196-2202.

PMID: # 16968783 Sohara, E. et al. 2006. Proc. Natl. Acad. Sci. USA. 103(38): 14217-14222.

PMID: # 16177794 Dodge-Kafka KL et al. 2005. Nature. 437(7058): 574-578.

PMID: # 16192372 Patwardhan, AM. et al. 2005. J Neurosci. 25(39): 8825-8832.

PMID: # 16083514 Yao, PL. et al. 2005. Respir. Res. 6: -.

PMID: # 15930146 Cheng, J. et al. 2005. Am. J. Physiol., Cell Physiol. 289: C959-C970.

PMID: # 11934820 Nagakura, A. et al. 2002. Br. J. Pharmacol. 135: 1783-1793.

인용 1 to 10 of 17 합계

매장선택

언어선택

화폐선택