ATAD3B Activators
ATAD3B activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of ATAD3B, a protein involved in mitochondrial dynamics and health. Resveratrol, for instance, acts by activating SIRT1, leading to the deacetylation of proteins that participate in mitochondrial processes, which could enhance the function of ATAD3B in these pathways. Similarly, Pioglitazone, a PPAR-gamma agonist, and Bezafibrate, a PPAR agonist, modulate mitochondrial function and biogenesis, potentially supporting the role of ATAD3B in mitochondrial fusion and overall health. ATAD3B, a mitochondrial protein, is critical for proper mitochondrial dynamics and function. The activity of ATAD3B is enhanced by a variety of chemical compounds, each acting upon different aspects of mitochondrial biology. Resveratrol, with its ability to activate SIRT1, indirectly supports ATAD3B activity by promoting deacetylation of mitochondrial proteins, potentially including those involved with ATAD3B function, thus facilitating mitochondrial fusion and biogenesis. Pioglitazone and Bezafibrate, through their action as PPAR agonists, can lead to increased mitochondrial biogenesis, which may indirectly enhance ATAD3B function within the mitochondrial network.
Further expanding the repertoire of ATAD3B activators are compounds like Metformin and AICAR, which activate AMPK, a cellular energy sensor that promotes mitochondrial biogenesis, potentially supporting ATAD3B's role in mitochondrial dynamics. Oleoylethanolamide, by activating PPAR-alpha, influences lipid metabolism and mitochondrial function, which could also support ATAD3B's activity. Additionally, Urolithin A, known for inducing mitophagy, might indirectly enhance ATAD3B's role by maintaining mitochondrial quality. The SIRT1-specific activator SRT1720, along with Quercetin, which also activates SIRT1, could further enhance deacetylation processes, indirectly benefiting ATAD3B's role in mitochondrial regulation. Lastly, Pyrroloquinoline quinone (PQQ) influences mitochondrial biogenesis and function, which may support the activity of ATAD3B in maintaining mitochondrial integrity and facilitating effective mitochondrial dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound known to activate SIRT1, which in turn can influence mitochondrial biogenesis and function. Since ATAD3B is involved in mitochondrial organization and dynamics, the activation of SIRT1 by Resveratrol could enhance ATAD3B function related to maintaining mitochondrial integrity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor to NAD+, which is a substrate for sirtuins, another group of proteins implicated in mitochondrial function. By increasing cellular NAD+ levels, NMN could indirectly enhance the activity of ATAD3B in mitochondrial regulation. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a fibrate drug that activates peroxisome proliferator-activated receptors (PPARs), which can influence mitochondrial DNA replication and transcription. This action might indirectly enhance ATAD3B’s role in mitochondrial biogenesis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator that can increase mitochondrial biogenesis and function. Through the activation of AMPK, AICAR may indirectly promote ATAD3B's role in maintaining mitochondrial health. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
Mdivi-1 is a selective inhibitor of mitochondrial division. By inhibiting mitochondrial fission, Mdivi-1 could enhance ATAD3B activity by stabilizing mitochondrial dynamics, where ATAD3B is known to be involved. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that affects mitochondrial biogenesis and function. As ATAD3B is implicated in mitochondrial dynamics, Pioglitazone could indirectly enhance ATAD3B function by modulating mitochondrial biogenesis. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMPK, which can lead to increased mitochondrial biogenesis and function. Through AMPK activation, Metformin might indirectly enhance the activity of ATAD3B in mitochondrial regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of cell growth and metabolism, including mitochondrial function. Inhibition of mTOR could result in the upregulation of mitochondrial activities where ATAD3B is implicated. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $204.00 $459.00 $714.00 $1224.00 | 10 | |
Urolithin A induces mitophagy, the selective degradation of mitochondria. By promoting mitophagy, Urolithin A could indirectly influence ATAD3B activity related to mitochondrial quality control. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression and cellular differentiation, with potential effects on mitochondrial biogenesis. This could lead to an indirect enhancement of ATAD3B activity in mitochondria. | ||||||