ASB-2 Activators
ASB-2 activators are a diverse group of chemicals that can indirectly enhance the functional activity of ASB-2 by influencing related pathways or cellular processes. They include compounds that inhibit nuclear export (Leptomycin B), mTOR (Rapamycin), the proteasome (MG132, ALLN, Epoxomicin, Lactacystin), autophagy (Chloroquine, Bafilomycin A1), protein synthesis (Cycloheximide), PI3K (LY294002, Wortmannin), and MEK (PD98059). These compounds generally work by shifting the balance of cellular processes towards protein degradation, which can potentially enhance the function of ASB-2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
This compound is known to inhibit nuclear export, thereby potentially increasing the concentration of proteins such as ASB-2 in the nucleus. This increased nuclear concentration can enhance ASB-2's ability to execute its functions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR is a central regulator of cell growth and proliferation. By inhibiting mTOR, Rapamycin can potentially enhance the protein degradation process where ASB-2 plays a significant role. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor. While it doesn't directly activate ASB-2, it can indirectly enhance ASB-2's function by inhibiting proteasome-mediated degradation, hence increasing the concentration of proteins like ASB-2 in the cells. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an autophagy inhibitor. By inhibiting autophagy, Chloroquine can potentially shift the balance of protein degradation towards the ubiquitin-proteasome system, hence potentially enhancing ASB-2's function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
This compound is an autophagy inhibitor. Similar to Chloroquine, Bafilomycin A1 can potentially shift the balance of protein degradation towards the ubiquitin-proteasome system, potentially enhancing ASB-2's function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor. By inhibiting protein synthesis, Cycloheximide can potentially enhance protein degradation processes where ASB-2 plays a significant role. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a proteasome inhibitor. Similar to MG132 and ALLN, it can increase the concentration of proteins including ASB-2 in the cells, hence potentially enhancing ASB-2's function. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor. It functions similarly to MG132, ALLN, and Epoxomicin by potentially enhancing ASB-2's function through increasing protein concentration in cells. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in cell growth and proliferation. By inhibiting PI3K, LY294002 can potentially enhance the protein degradation process where ASB-2 plays a significant role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor. MEK is involved in the MAPK/ERK pathway, which is related to cell growth and proliferation. By inhibiting MEK, PD98059 can potentially enhance the protein degradation process where ASB-2 plays a significant role. | ||||||