ARRDC1 Activators
The biological functioning of ARRDC1 can be influenced by several chemical compounds. Forskolin, Cilostazol, Rolipram, and IBMX are key activators of this protein. They increase the intracellular level of cAMP, resulting in the activation of PKA (Protein Kinase A). PKA can phosphorylate ARRDC1, thereby enhancing its functional activity. H-89, an inhibitor of PKA, enhances the functional activity of ARRDC1 by increasing the accumulation of its non-phosphorylated state. Calmodulin, a calcium-binding protein, can activate CaMKII (Calcium/Calmodulin-dependent Protein Kinase II), which can then phosphorylate and activate ARRDC1.
Moreover, compounds like Quinidine, Verapamil, A23187, Thapsigargin, and Ionomycin can also enhance the functional activity of ARRDC1 by increasing intracellular Ca2+ levels. This leads to the activation of CaMKII, which then phosphorylates and activates ARRDC1. For instance, Quinidine is a blocker of voltage-gated K+ channels and may alter membrane potential and intracellular Ca2+ levels, triggering the activation of CaMKII, and subsequently ARRDC1. Similarly, Verapamil blocks calcium influx, leading to an increase in intracellular Ca2+ that activates CaMKII, which then phosphorylates and activates ARRDC1.The biological functioning of ARRDC1 can be influenced by several chemical compounds. Forskolin, Cilostazol, Rolipram, and IBMX are key activators of this protein. They increase the intracellular level of cAMP, resulting in the activation of PKA (Protein Kinase A). PKA can phosphorylate ARRDC1, thereby enhancing its functional activity. H-89, an inhibitor of PKA, enhances the functional activity of ARRDC1 by increasing the accumulation of its non-phosphorylated state. Calmodulin, a calcium-binding protein, can activate CaMKII (Calcium/Calmodulin-dependent Protein Kinase II), which can then phosphorylate and activate ARRDC1.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in the intracellular level of cAMP. The increase in cAMP can then activate PKA (Protein Kinase A), which can phosphorylate and activate ARRDC1. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin is a calcium-binding protein that activates CaMKII (Calcium/Calmodulin-dependent Protein Kinase II). CaMKII can phosphorylate and activate ARRDC1, thereby enhancing its functional activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of CaMKII. By inhibiting CaMKII, KN-93 can increase the accumulation of non-phosphorylated ARRDC1, enhancing its functional activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a PDE3 (phosphodiesterase 3) inhibitor. It can increase the intracellular level of cAMP, leading to the activation of PKA, which can phosphorylate and activate ARRDC1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of PDE4 (phosphodiesterase 4). By enhancing the intracellular level of cAMP, it leads to the activation of PKA, which can phosphorylate and activate ARRDC1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of PDE (phosphodiesterase). By inhibiting PDE, IBMX can increase the cAMP level, leading to the activation of PKA, which can phosphorylate and activate ARRDC1. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine is a blocker of voltage-gated K+ channels. This may lead to alterations in membrane potential and intracellular Ca2+ levels, which could activate CaMKII, leading to the phosphorylation and activation of ARRDC1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker. By blocking calcium influx, it can lead to an increase in intracellular Ca2+ level, activating CaMKII, which can phosphorylate and activate ARRDC1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion-carrier that transports Ca2+ across biological membranes. Increased intracellular Ca2+ level can activate CaMKII, leading to the phosphorylation and activation of ARRDC1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the SERCA (Sarco/Endoplasmic Reticulum Ca2+ ATPase) pump, leading to an increase in intracellular Ca2+ level, which can activate CaMKII, leading to the activation of ARRDC1. | ||||||