ARL8B Inhibitors
ARL8B inhibitors belong to a specific chemical class that has garnered attention for its role in modulating cellular processes. These inhibitors are designed to target and interact with ARL8B, a member of the ADP-ribosylation factor-like (ARL) family of small GTPases. ARL8B plays a pivotal role in regulating intracellular vesicular trafficking, organelle positioning, and lysosomal dynamics. The inhibitors exert their effects by binding to ARL8B and modulating its GTPase activity, thereby influencing its function as a molecular switch in various cellular pathways.
By specifically targeting ARL8B, these inhibitors offer a means to selectively manipulate cellular processes that rely on ARL8B-mediated vesicular transport and organelle positioning. Their ability to perturb these intracellular mechanisms opens up avenues for elucidating the underlying molecular mechanisms and exploring potential cellular responses. The study and development of ARL8B inhibitors contribute to advancing our understanding of cellular biology and may have implications in diverse research fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Although not a specific ARL8B inhibitor, BFA is a well-known inhibitor of various small GTPases, including ARL8B, by disrupting the Golgi apparatus and altering intracellular trafficking. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of the related small GTPase, ARL3, which shares homology with ARL8B. It might also have an effect on ARL8B activity. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Although primarily recognized as an inhibitor of the Gq protein, YM-254890 has been implicated in affecting vesicular trafficking and could have an impact on ARL8B-related processes. | ||||||
CID-44216842 | 1222513-26-9 | sc-507406 | 5 mg | $285.00 | ||
A compound reported to inhibit ARL8B-mediated lysosomal repositioning and trafficking. | ||||||