| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A functions as a potent ARF by disrupting the Golgi apparatus and endoplasmic reticulum dynamics. It specifically inhibits the guanine nucleotide exchange factor (GEF) activity, leading to the inactivation of ARF proteins. This compound alters membrane trafficking by preventing the recruitment of coat proteins, thereby affecting vesicle formation. Its unique ability to induce organelle fusion highlights its role in modulating intracellular transport mechanisms. | ||||||
ARF inhibitor | sc-3030 | 0.5 mg | $95.00 | 1 | ||
ARF inhibitors are characterized by their ability to modulate the activity of ADP-ribosylation factors, impacting cellular signaling pathways. These compounds interact with specific protein domains, altering the conformational state of ARF proteins. By inhibiting GTP binding, they disrupt the activation cycle of ARF, leading to changes in cytoskeletal dynamics and membrane organization. Their influence on vesicle budding and transport processes underscores their role in cellular homeostasis. | ||||||
ARF Inhibitory Peptide (P-13) | sc-200866 | 1 mg | $127.00 | |||
ARF Inhibitory Peptide (P-13) functions by selectively disrupting the interaction between ARF proteins and their downstream effectors. This peptide binds to the ARF GTPase, preventing its activation and subsequent signaling cascades. By interfering with the nucleotide exchange process, P-13 alters the dynamics of membrane trafficking and cytoskeletal rearrangements. Its unique ability to modulate protein-protein interactions highlights its significance in regulating cellular architecture and function. | ||||||