Arc Inhibitors
Common Arc Inhibitors include, but are not limited to Rapamycin CAS 53123-88-9, Wortmannin CAS 19545-26-7, LY 294002 CAS 154447-36-6, U-0126 CAS 109511-58-2 and PD 98059 CAS 167869-21-8.
Arc, also known as Activity-regulated cytoskeleton-associated protein, is a protein that has gained attention for its unique role in synaptic plasticity and neuronal activity. Synaptic plasticity is the ability of synapses to strengthen or weaken over time in response to changes in their activity. Arc plays an indispensable role in this process, especially in the consolidation of long-term memories. It is synthesized in response to various forms of synaptic activity and has been identified as a critical component in both long-term potentiation and long-term depression, two fundamental mechanisms underlying learning and memory in the brain.
Arc inhibitors are molecules designed to specifically target and reduce the activity or expression of the Arc protein. The role of Arc in synaptic modifications suggests that its modulation could have profound effects on neuronal communication and the overall functionality of neural networks. By inhibiting Arc, these compounds can influence the dynamic changes occurring at synapses and, consequently, the overall patterns of neuronal activity in the brain. The exact mechanisms through which Arc inhibitors function can vary; some might prevent the synthesis of Arc, while others might interfere with its activity or its interactions with other proteins in the neuron.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Since mTOR signaling can regulate Arc expression, its inhibition might down-regulate Arc. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits PI3K, which is upstream of mTOR. Inhibition of this pathway might lead to reduced Arc expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor, LY294002 might down-regulate Arc by inhibiting signaling pathways that regulate its expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Like U0126, PD98059 is a MEK inhibitor and might down-regulate Arc through the MAPK/ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. JNK pathways can influence Arc, so its inhibition might reduce Arc levels. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This compound inhibits p38 MAPK, which might influence pathways regulating Arc expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that might influence neuronal activity and, indirectly, Arc expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis, which might directly down-regulate Arc protein levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By inhibiting RNA synthesis, actinomycin D can down-regulate the expression of many proteins, including Arc. | ||||||
D(−)-2-Amino-5-phosphonovaleric acid (D-AP5) | 79055-68-8 | sc-200434 | 5 mg | $97.00 | 2 | |
APV is an NMDA receptor antagonist. Since NMDA receptor activity can induce Arc expression, its inhibition might reduce Arc levels. | ||||||