APHC Activators
APHC Activators are a group of chemical compounds that can enhance the functional activity of ACER3, a critical enzyme in sphingolipid metabolism. Compounds like C6-Ceramide and C2-Ceramide serve as substrates for ACER3, potentially activating its enzymatic activity by providing additional substrate for hydrolysis. The presence of Sphingosine and Sphinganine, as products and precursors in the ceramide metabolism pathway, might also enhance ACER3 activity by affecting substrate availability and feedback mechanisms.
GW4869, which influences sphingomyelin levels, could indirectly modulate ACER3's role in ceramide metabolism. Sphingosine kinase inhibitors like D-MAPP, by altering the levels of sphingosine-1-phosphate, a key sphingolipid metabolite, might also influence ACER3 activity. Additionally, SRT1720, as an activator of SIRT1, could indirectly affect ACER3 activity due to its role in lipid metabolism regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
As a product of ceramide hydrolysis, exogenous sphingosine could enhance ACER3 activity by substrate feedback. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
As a signaling molecule in sphingolipid metabolism, it could modulate ACER3 activity. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Another short-chain ceramide that can serve as a substrate for ACER3, potentially activating its enzymatic function. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
Activates SIRT1, a protein involved in lipid metabolism, which could indirectly influence ACER3 activity. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
An inhibitor of neutral sphingomyelinase, altering ceramide levels and potentially affecting ACER3 activity. | ||||||