AP1S2 Activators
AP1S2 activators are a class of chemical compounds known for their ability to modulate the activity of the AP-1 complex subunit sigma-2 (AP1S2). The AP-1 complex is a key player in intracellular protein trafficking, particularly in the process of vesicle formation and sorting. AP1S2 is one of the subunits of the AP-1 complex and plays a crucial role in mediating protein-protein interactions necessary for vesicle formation. By activating AP1S2, these compounds can potentially enhance the efficiency of protein trafficking within cells, leading to improved cellular functions and homeostasis.
The mechanism by which AP1S2 activators exert their effects is not yet fully understood, but it is believed to involve the modulation of AP1S2 interactions with other subunits of the AP-1 complex and with cargo proteins. By binding to AP1S2, these compounds may stabilize the interactions necessary for vesicle formation, thereby increasing the efficiency of protein trafficking. This, in turn, could lead to improved cellular functions such as receptor recycling, secretion of signaling molecules, and maintenance of organelle integrity. Research into AP1S2 activators is ongoing, with the ultimate goal of understanding and manipulating intracellular protein trafficking for various cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels which can enhance vesicular trafficking processes where AP1S2 plays a role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C which plays a role in vesicle formation and might indirectly increase the demand for AP1S2 function. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
It acts as a signaling molecule and can enhance vesicular transport, thus potentially increasing AP1S2 function. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a precursor to signaling molecules, it might indirectly modulate vesicular trafficking pathways involving AP1S2. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
As a signaling lipid, it has roles in endocytosis and might indirectly promote AP1S2-related functions. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
A secondary messenger, cAMP, can influence numerous signaling pathways, potentially enhancing vesicular trafficking processes where AP1S2 is involved. | ||||||